Lee Wei Lim

2025

Data Mining Approach to Melatonin Treatment in Alzheimer’s Disease: New Gene Targets MMP2 and NR3C1

Zhang, J., Tsui, K. C., Lee, H. Y., Aquili, L., Wong, K. H., Kocabicak, E., Temel, Y., Lu, Z., Fung, M. L., Kalueff, A. & Lim, L. W., Jan 2025, In: International Journal of Molecular Sciences. 26, 1, 338.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Developing zebrafish models of Notch-related CNS pathologies

Erofeeva, N., Galstyan, D. S., Yang, L., Strekalova, T., Lim, L. W., de Abreu, M. S., Golushko, N. I., Stewart, A. M. & Kalueff, A. V., Mar 2025, In: Neuroscience and Biobehavioral Reviews. 170, 106059.

Research output: Contribution to journal › Review article › peer-review

Developing zebrafish models of Notch-related CNS pathologies

Erofeeva, N., Galstyan, D. S., Yang, L., Strekalova, T., Lim, L. W., Abreu, M. S. D., Golushko, N. I., Stewart, A. M. & Kaluev, A., 8 Feb 2025, In: Neuroscience and Biobehavioral Reviews. 170, 106059.

Research output: Contribution to journal › Article › peer-review

Ganoderma lucidum: An Emerging Nutritional Approach to Manage Depression

Jin, H., Aquili, L., Heng, B. C., Strekalova, T., Fung, M. L., Tipoe, G. L., Kocabicak, E., Blokland, A., Temel, Y., Lu, Z., Kalueff, A., Wong, K. H. & Lim, L. W., 2025, (Accepted/In press) In: Food Reviews International.

Research output: Contribution to journal › Review article › peer-review

Ganoderma lucidum: an emerging nutritional approach to manage depression

Jin, H., Aquili, L., Heng, B. C., Strekalova, T., Fung, M-L., Tipoe, G. L., Kocabicak, E., Blokland, A., Temel, Y., Lu, Z., Kaluev, A., Wong, K. H. & Lim, L. W., 24 Feb 2025, In: Food Reviews International.

Research output: Contribution to journal › Review article › peer-review

Open Access

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199 Downloads (Pure)

Neurotranscriptomic and behavioral effects of ISRIB, and its therapeutic effects in the traumatic brain injury model in zebrafish

Ilyin, N. P., Shevlyakov, A. D., Boyko, G. A., Moskalenko, A. M., Ikrin, A. N., Galstyan, D. S., Kolesnikova, T. O., Katolikova, N. V., Chekrygin, S. A., Lim, L. W., Yang, L., De Abreu, M. S., Yenkoyan, K. B., Demin, K. A. & Kaluev, A., 1 Feb 2025, In: Brain Research. 1848, 149329.

Research output: Contribution to journal › Article › peer-review

Past, present, and future of serotonin-targeting therapeutics for Alzheimer’s disease: Perspectives from DNA methylation

Liu, Y., Aquili, L., Wong, K. H., Lu, Z. & Lim, L. W., Jun 2025, In: Ageing Research Reviews. 108, 102755.

Research output: Contribution to journal › Article › peer-review

Trace amine signaling in zebrafish models: CNS pharmacology, behavioral regulation and translational relevance

Galstyan, D. S., Krotova, N. A., Lebedev, A. S., Kotova, M. M., Martynov, D. D., Golushko, N. I., Perederiy, A. S., Zhukov, I. S., Rosemberg, D. B., Lim, L. W., Yang, L., Abreu, M. S. D., Gainetdinov, R. R. & Kaluev, A., 25 Jan 2025, In: European Journal of Pharmacology. 991, 177312, 10.1016/j.ejphar.2025.177312.

Research output: Contribution to journal › Article › peer-review

Using Zebrafish Models to Study Epitranscriptomic Regulation of CNS Functions

Jiang, J., Zhang, Y., Wang, J., Qin, Y., Zhao, C., He, K., Wang, C., Liu, Y., Feng, H., Cai, H., He, S., Li, R., Galstyan, D. S., Yang, L., Lim, L. W., de Abreu, M. S. & Kalueff, A. V., Jan 2025, In: Journal of Neurochemistry. 169, 1, e16311.

Research output: Contribution to journal › Review article › peer-review

Using Zebrafish Models to Study Epitranscriptomic Regulation of CNS Functions

Jiayou, J., Yunqian, Z., Jiyi, W., Yixin, Q., Chonguang, Z., Kai, H., Chaoming, W., Yucheng, L., Haoyu, F., Huiling, C., Shulei, H., Ruiyu, L., Galstyan, D. S., Yang, L., Lim, L. W., S de Abreu, M. & Kaluev, A., Jan 2025, In: Journal of Neurochemistry. 169, 1, e16311.

Research output: Contribution to journal › Article › peer-review

2024

An Injectable Hydrogel Loaded with GMSCs-Derived Neural Lineage Cells Promotes Recovery after Stroke

Jiang, S., Yuan, C., Zou, T., Koh, J. H., Basabrain, M., Chen, Q., Liu, J., Heng, B. C., Lim, L. W., Wang, P. & Zhang, C., 1 Sept 2024, In: Tissue Engineering - Part A. 30, 17-18, p. 563-576 14 p.

Research output: Contribution to journal › Article › peer-review

Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs: Deliriant Antihistaminic Drugs

Nerush, M. O., Shevyrin, V. A., Golushko, N. I., Moskalenko, A. M., Rosemberg, D. B., De Abreu, M. S., Yang, L. E., Galstyan, D. S., Lim, L. W., Demin, K. A. & Kalueff, A. V., 30 Sept 2024, In: ACS Chemical Neuroscience. 15, 21, p. 3848-3862 15 p.

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Dietary tyrosine consumption modulates the effects of tDCS, but not tRNS, on planning behaviour

Buck, O., Found, T., Weldon, R., Lim, L. W. & Aquili, L., 1 May 2024, In: Brain Stimulation. 17, 3, p. 572-574 3 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

Expert Consensus on the Application of Stem Cells in Psoriasis Research and Clinical Trials

Kuang, Y-H., Zhu, W., Lin, G., Cheng, L-M., Qin, Q., Huang, Z-J., Shi, Y-L., Zhang, C-L., Xu, J-H., Yan, K-X., Lv, C-Z., Li, W., Han, Q., Stambler, I., Lim, L. W., Chakrabarti, S., Ulfhake, B., Min, K-J., Ellison-Hughes, G., Cho, W. C., & 5 othersJin, K., Yao, D., Lu, C., Zhao, R. C. & Chen, X., 23 Jun 2024, In: Aging and Disease.

Research output: Contribution to journal › Review article › peer-review

Open Access

Holistic approaches to healthy longevity. Handbook on Longevity Medicine: The Road Map.

Rattan, S., Bartke, A., Rose, M. R., Lim, L. W., Caruso, C., Ulfhake, B. & Olovnikov, A., 11 Aug 2024, European Wellness Academy.

Research output: Book/Report/Edited volume › Book › peer-review

Regulatory safeguards needed if preimplantation genetic testing for polygenic risk scores (PGT-P) is permitted in Singapore

Chin, A. H. B., Lim, L. W. & Muhsin, S. M., 2024, (Accepted/In press) In: Journal of Medical Ethics. jme-2023-109195.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Safety profile of subacute oral administration of ethanolic extract of Gracilaria manilaensis Yamamoto & Trono

Nyiew, K. Y., Wong, K. H., Lim, L. W., Lim, S. H., Phang, S. M., Shyamala, R. & Yow, Y. Y., Aug 2024, In: Journal of Applied Phycology. 36, 4, p. 2173-2182 10 p.

Research output: Contribution to journal › Article › peer-review

Transcorneal Stimulator for Treating Brain Diseases

Chan, L. L. H., Lim, L. W., Yu, W. S. & Agadagba, S. K., 14 Nov 2024, Patent No. US2024/0374895 A1, Priority No. US18/621,152

Research output: Patent

File

10 Downloads (Pure)

Transplantation of Neural Progenitor Cells Derived from Stem Cells from Apical Papilla Through Small-Molecule Induction in a Rat Model of Sciatic Nerve Injury

Koh, J., Liu, J., Poon, C. H., Kang, J., Basabrain, M. S., Lim, L. W. & Zhang, C., Aug 2024, In: Tissue Engineering and Regenerative Medicine. 21, 6, p. 867-879 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

2023

Adenosine Improves Mitochondrial Function and Biogenesis in Friedreich’s Ataxia Fibroblasts Following L-Buthionine Sulfoximine-Induced Oxidative Stress

Lew, S. Y., Mohd Hisam, N. S., Phang, M. W. L., Syed Abdul Rahman, S. N., Poh, R. Y. Y., Lim, S. H., Kamaruzzaman, M. A., Chau, S. C., Tsui, K. C., Lim, L. W. & Wong, K. H., Apr 2023, In: Biology. 12, 4, 559.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Advances in transcorneal electrical stimulation: From the eye to the brain

Agadagba, S. K., Lim, L. W. & Chan, L. L. H., 2023, In: Frontiers in Cellular Neuroscience. 17, 1134857.

Research output: Contribution to journal › Review article › peer-review

Open Access

8 Citations (Scopus)

Editorial: Natural products for neuroprotection and neuroregeneration

Wong, K. H., Lim, L. W., Mohd Hisam, N. S., Kamarudin, M. N. A. & Lakshmanan, H., 2023, In: Frontiers in Pharmacology. 14, 1209297.

Research output: Contribution to journal › Editorial

Open Access

Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions

Heng, B. C., Bai, Y., Li, X., Lim, L. W., Li, W., Ge, Z., Zhang, X. & Deng, X., 13 Jan 2023, In: Advanced Science. 10, 2, 2204502.

Research output: Contribution to journal › Review article › peer-review

Open Access

78 Citations (Scopus)

Functional MRI reveals brain-wide actions of thalamically-initiated oscillatory activities on associative memory consolidation

Wang, X., Leong, A. T. L., Tan, S. Z. K., Wong, E. C., Liu, Y., Lim, L. W. & Wu, E. X., Dec 2023, In: Nature Communications. 14, 1, 2195.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Hericium erinaceus Promotes Anti-Inflammatory Effects and Regulation of Metabolites in an Animal Model of Cerebellar Ataxia

Chau, S. C., Chong, P. S., Jin, H., Tsui, K. C., Khairuddin, S., Tse, A. C. K., Lew, S. Y., Tipoe, G. L., Lee, C. W., Fung, M. L., Wong, K. H. & Lim, L. W., Apr 2023, In: International Journal of Molecular Sciences. 24, 7, 6089.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Learning bias predicts fear acquisition under stress but not cognitive flexibility

Caudwell, K. M., Baldini, S., Calvezzi, G., Graham, A., Jackson, K., Johansson, I., Sines, M., Lim, L. W. & Aquili, L., 1 Dec 2023, In: Physiology and Behavior. 272, 114384.

Research output: Contribution to journal › Article › peer-review

Open Access

Malaysian brown macroalga Padina australis mitigates lipopolysaccharide-stimulated neuroinflammation in BV2 microglial cells

Subermaniam, K., Lew, S. Y., Yow, Y. Y., Lim, S. H., Yu, W. S., Lim, L. W. & Wong, K. H., Jun 2023, In: Iranian Journal of Basic Medical Sciences. 26, 6, p. 669-679 11 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's disease

Li, S., Poon, C. H., Zhang, Z., Yue, M., Chen, R., Zhang, Y., Hossain, M. F., Pan, Y., Zhao, J., Rong, L., Chu, L. W., Shea, Y. F., Rogaeva, E., Tu, J., St George-Hyslop, P., Lim, L. W. & Song, Y. Q., Jul 2023, In: CNS Neuroscience and Therapeutics. 29, 7, p. 1848-1864 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Citations (Scopus)

Molecular signature of excessive female aggression: study of stressed mice with genetic inactivation of neuronal serotonin synthesis

Strekalova, T., Moskvin, O., Jain, A. Y., Gorbunov, N., Gorlova, A., Sadovnik, D., Umriukhin, A., Cespuglio, R., Yu, W. S., Tse, A. C. K., Kalueff, A. V., Lesch, K. P. & Lim, L. W., Sept 2023, In: Journal of Neural Transmission. 130, 9, p. 1113-1132 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Prelimbic Cortical Stimulation Induces Antidepressant-like Responses through Dopaminergic-Dependent and -Independent Mechanisms

Khairuddin, S., Lim, W. L., Aquili, L., Tsui, K. C., Tse, A. C. K., Jayalath, S., Varma, R., Sharp, T., Benazzouz, A., Steinbusch, H., Blokland, A., Temel, Y. & Lim, L. W., Jun 2023, In: Cells. 12, 11, 1449.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Prelimbic Cortical Stimulation with L-methionine Enhances Cognition through Hippocampal DNA Methylation and Neuroplasticity Mechanisms

Poon, C. H., Liu, Y., Pak, S., Zhao, R. C., Aquili, L., Tipoe, G. L., Leung, G. K. K., Chan, Y. S., Yang, S., Fung, M. L., Wu, E. X. & Lim, L. W., 1 Feb 2023, In: Aging and Disease. 14, 1, p. 112-135 24 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Routine behaviour, a putative dopamine marker, predicts cognitive flexibility by tDCS of the dlPFC

Yatan, G., Lim, L. W. & Aquili, L., 1 Jan 2023, In: Brain Stimulation. 16, 1, p. 108-110 3 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

2 Citations (Scopus)

Sex Differences between Neuronal Loss and the Early Onset of Amyloid Deposits and Behavioral Consequences in 5xFAD Transgenic Mouse as a Model for Alzheimer’s Disease

Poon, C. H., Wong, S. T. N., Roy, J., Wang, Y., Chan, H. W. H., Steinbusch, H., Blokland, A., Temel, Y., Aquili, L. & Lim, L. W., Mar 2023, In: Cells. 12, 5, 780.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Citations (Scopus)

2022

Altered synaptic plasticity of the longitudinal dentate gyrus network in noise-induced anxiety

Pak, S., Choi, G., Roy, J., Poon, C. H., Lee, J., Cho, D., Lee, M., Lim, L. W., Bao, S., Yang, S. & Yang, S., 17 Jun 2022, In: iScience. 25, 6, 104364.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

Antidepressant-like effects of transcorneal electrical stimulation in rat models

Yu, W. S., Tse, A. C. K., Guan, L., Chiu, J. L. Y., Tan, S. Z. K., Khairuddin, S., Agadagba, S. K., Lo, A. C. Y., Fung, M. L., Chan, Y. S., Chan, L. L. H. & Lim, L. W., 1 May 2022, In: Brain Stimulation. 15, 3, p. 843-856 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Citations (Scopus)

Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives

Strekalova, T., Liu, Y., Kiselev, D., Khairuddin, S., Chiu, J. L. Y., Lam, J., Chan, Y. S., Pavlov, D., Proshin, A., Lesch, K. P., Anthony, D. C. & Lim, L. W., Mar 2022, In: Psychopharmacology. 239, 3, p. 663-693 31 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

82 Citations (Scopus)

Discovering the Potential of Natural Antioxidants in Age-Related Macular Degeneration: A Review

Wong, K. H., Nam, H. Y., Lew, S. Y., Naidu, M., David, P., Kamalden, T. A., Hadie, S. N. H. & Lim, L. W., Jan 2022, In: Pharmaceuticals. 15, 1, 101.

Research output: Contribution to journal › Review article › peer-review

Open Access

18 Citations (Scopus)

Discovery of Therapeutics Targeting Oxidative Stress in Autosomal Recessive Cerebellar Ataxia: A Systematic Review

Lew, S. Y., Phang, M. W. L., Chong, P. S., Roy, J., Poon, C. H., Yu, W. S., Lim, L. W. & Wong, K. H., Jun 2022, In: Pharmaceuticals. 15, 6, 764.

Research output: Contribution to journal › Review article › peer-review

Open Access

11 Citations (Scopus)

Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer’s disease

Tsui, K. C., Roy, J., Chau, S. C., Wong, K. H., Shi, L., Poon, C. H., Wang, Y., Strekalova, T., Aquili, L., Chang, R. C. C., Fung, M. L., Song, Y. Q. & Lim, L. W., 28 Jul 2022, In: Frontiers in Aging Neuroscience. 14, 964336.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Citations (Scopus)

Eyeblink rate, a putative dopamine marker, predicts negative reinforcement learning by tDCS of the dlPFC

Prowacki, M., Lim, L. W. & Aquili, L., 1 May 2022, In: Brain Stimulation. 15, 3, p. 533-535 3 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

6 Citations (Scopus)

Glial cells in Alzheimer's disease: From neuropathological changes to therapeutic implications

Uddin, M. S. & Lim, L. W., Jun 2022, In: Ageing Research Reviews. 78, 101622.

Research output: Contribution to journal › Review article › peer-review

80 Citations (Scopus)

How have COVID-19 stringency measures changed scholarly activity?

Caudwell, K. M., Soranzo, A., Lim, L. W. & Aquili, L., Jul 2022, In: Annals of the New York Academy of Sciences. 1513, 1, p. 5-9 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Neuromodulation and hippocampal neurogenesis in depression: A scoping review

Flores, A. D., Yu, W. S., Fung, M. L. & Lim, L. W., 1 Oct 2022, In: Brain Research Bulletin. 188, p. 92-107 16 p.

Research output: Contribution to journal › Review article › peer-review

18 Citations (Scopus)

Predation Stress Causes Excessive Aggression in Female Mice with Partial Genetic Inactivation of Tryptophan Hydroxylase-2: Evidence for Altered Myelination-Related Processes

Svirin, E., Veniaminova, E., Costa-Nunes, J. P., Gorlova, A., Umriukhin, A., Kalueff, A. V., Proshin, A., Anthony, D., Nedorubov, A., Tse, A. C. K., Walitza, S., Lim, L. W., Lesch, K. P. & Strekalova, T., 18 Mar 2022, In: Cells. 11, 6, 1036.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies

Roy, J., Wong, K. Y., Aquili, L., Uddin, M. S., Heng, B. C., Tipoe, G. L., Wong, K. H., Fung, M. L. & Lim, L. W., Apr 2022, In: Frontiers in Neuroendocrinology. 65, 100986.

Research output: Contribution to journal › Review article › peer-review

46 Citations (Scopus)

Tetratricopeptide repeat domain 9A knockout induces social anxiety and impairs offense behaviors in female mice

Yu, W. S., Guan, L., Tan, S. Z. K., Shrestha, S., Or, Y. Z., Lufkin, T., Lin, V. C. L. & Lim, L. W., Jun 2022, In: Iranian Journal of Basic Medical Sciences. 25, 6, p. 698-703 6 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

The Monkey Head Mushroom and Memory Enhancement in Alzheimer’s Disease

Yanshree, Yu, W. S., Fung, M. L., Lee, C. W., Lim, L. W. & Wong, K. H., Aug 2022, In: Cells. 11, 15, 2284.

Research output: Contribution to journal › Review article › peer-review

Open Access

16 Citations (Scopus)

Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models

Yu, W. S., Aquili, L., Wong, K. H., Lo, A. C. Y., Chan, L. L. H., Chan, Y. S. & Lim, L. W., Sept 2022, In: Annals of the New York Academy of Sciences. 1515, 1, p. 249-265 17 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

2021

A Brief Comparative Look at Experimental Memory Editing Techniques for Cognitive Dysfunction

Poon, C. H., Tan, S. Z. K., Sheng, V., Wang, S., Aquili, L. & Lim, L. W., Sept 2021, In: Current Alzheimer Research. 18, 10, p. 841-848 8 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

An existentialist approach to authentic science

Tan, S. Z. K. & Lim, L. W., Dec 2021, In: IBRO Neuroscience Reports. 11, p. 52-55 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Lee Wei Lim

Research output

Search results