TY - JOUR
T1 - Developing zebrafish models of Notch-related CNS pathologies
AU - Erofeeva, Natalia
AU - Galstyan, David S.
AU - Yang, Longen
AU - Strekalova, Tatiana
AU - Lim, Lee Wei
AU - de Abreu, Murilo S.
AU - Golushko, Nikita I.
AU - Stewart, Adam Michael
AU - Kalueff, Allan V.
N1 - Publisher Copyright:
© 2025 Elsevier Ltd
PY - 2025/3
Y1 - 2025/3
N2 - Notch signaling is an evolutionarily conserved cellular pathway that regulates various stem cell functions, including fate determination, differentiation, proliferation, and apoptosis. This crucial signaling mechanism also plays an important role in the brain, regulating neurogenesis, cell differentiation, and homeostasis, whereas disrupted Notch signaling is linked to various neurodegenerative diseases and brain cancers. Here, we review the central nervous system (CNS) pathologies associated with aberrant Notch signaling, and summarize the available experimental (animal) models used to study these pathologies, with a special focus on zebrafish (Danio rerio). As genetic, pharmacological, and behavioral models in zebrafish have significantly advanced our understanding of Notch-related CNS disorders, future research is expected to further link Notch signaling to brain disorders and, eventually, lead to their more specific and targeted therapeuties.
AB - Notch signaling is an evolutionarily conserved cellular pathway that regulates various stem cell functions, including fate determination, differentiation, proliferation, and apoptosis. This crucial signaling mechanism also plays an important role in the brain, regulating neurogenesis, cell differentiation, and homeostasis, whereas disrupted Notch signaling is linked to various neurodegenerative diseases and brain cancers. Here, we review the central nervous system (CNS) pathologies associated with aberrant Notch signaling, and summarize the available experimental (animal) models used to study these pathologies, with a special focus on zebrafish (Danio rerio). As genetic, pharmacological, and behavioral models in zebrafish have significantly advanced our understanding of Notch-related CNS disorders, future research is expected to further link Notch signaling to brain disorders and, eventually, lead to their more specific and targeted therapeuties.
KW - Animal model
KW - Neurodegeneration
KW - Notch signaling pathway
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85217821969&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2025.106059
DO - 10.1016/j.neubiorev.2025.106059
M3 - Review article
AN - SCOPUS:85217821969
SN - 0149-7634
VL - 170
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
M1 - 106059
ER -
