Lee Wei Lim

2025

Data Mining Approach to Melatonin Treatment in Alzheimer’s Disease: New Gene Targets MMP2 and NR3C1

Zhang, J., Tsui, K. C., Lee, H. Y., Aquili, L., Wong, K. H., Kocabicak, E., Temel, Y., Lu, Z., Fung, M. L., Kalueff, A. & Lim, L. W., Jan 2025, In: International Journal of Molecular Sciences. 26, 1, 338.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Developing zebrafish models of Notch-related CNS pathologies

Erofeeva, N., Galstyan, D. S., Yang, L., Strekalova, T., Lim, L. W., Abreu, M. S. D., Golushko, N. I., Stewart, A. M. & Kaluev, A., 8 Feb 2025, In: Neuroscience and Biobehavioral Reviews. 170, 106059.

Research output: Contribution to journal › Article › peer-review

Experimental modeling of Alzheimer's disease: Translational lessons from cross-taxon analyses

B Yenkoyan, K., Kaluev, A., Yang, L. & Lim, L. W., 27 May 2025, In: Alzheimer's & Dementia. 21, (5), e70273.

Research output: Contribution to journal › Article › peer-review

Neurotranscriptomic and behavioral effects of ISRIB, and its therapeutic effects in the traumatic brain injury model in zebrafish

Ilyin, N. P., Shevlyakov, A. D., Boyko, G. A., Moskalenko, A. M., Ikrin, A. N., Galstyan, D. S., Kolesnikova, T. O., Katolikova, N. V., Chekrygin, S. A., Lim, L. W., Yang, L., De Abreu, M. S., Yenkoyan, K. B., Demin, K. A. & Kaluev, A., 1 Feb 2025, In: Brain Research. 1848, 149329.

Research output: Contribution to journal › Article › peer-review

Past, present, and future of serotonin-targeting therapeutics for Alzheimer’s disease: Perspectives from DNA methylation

Liu, Y., Aquili, L., Wong, K. H., Lu, Z. & Lim, L. W., Jun 2025, In: Ageing Research Reviews. 108, 102755.

Research output: Contribution to journal › Article › peer-review

Trace amine signaling in zebrafish models: CNS pharmacology, behavioral regulation and translational relevance

Galstyan, D. S., Krotova, N. A., Lebedev, A. S., Kotova, M. M., Martynov, D. D., Golushko, N. I., Perederiy, A. S., Zhukov, I. S., Rosemberg, D. B., Lim, L. W., Yang, L., Abreu, M. S. D., Gainetdinov, R. R. & Kaluev, A., 25 Jan 2025, In: European Journal of Pharmacology. 991, 177312, 10.1016/j.ejphar.2025.177312.

Research output: Contribution to journal › Article › peer-review

Using Zebrafish Models to Study Epitranscriptomic Regulation of CNS Functions

Jiayou, J., Yunqian, Z., Jiyi, W., Yixin, Q., Chonguang, Z., Kai, H., Chaoming, W., Yucheng, L., Haoyu, F., Huiling, C., Shulei, H., Ruiyu, L., Galstyan, D. S., Yang, L., Lim, L. W., S de Abreu, M. & Kaluev, A., Jan 2025, In: Journal of Neurochemistry. 169, 1, e16311.

Research output: Contribution to journal › Article › peer-review

2024

An Injectable Hydrogel Loaded with GMSCs-Derived Neural Lineage Cells Promotes Recovery after Stroke

Jiang, S., Yuan, C., Zou, T., Koh, J. H., Basabrain, M., Chen, Q., Liu, J., Heng, B. C., Lim, L. W., Wang, P. & Zhang, C., 1 Sept 2024, In: Tissue Engineering - Part A. 30, 17-18, p. 563-576 14 p.

Research output: Contribution to journal › Article › peer-review

Regulatory safeguards needed if preimplantation genetic testing for polygenic risk scores (PGT-P) is permitted in Singapore

Chin, A. H. B., Lim, L. W. & Muhsin, S. M., 2024, (Accepted/In press) In: Journal of Medical Ethics. jme-2023-109195.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Safety profile of subacute oral administration of ethanolic extract of Gracilaria manilaensis Yamamoto & Trono

Nyiew, K. Y., Wong, K. H., Lim, L. W., Lim, S. H., Phang, S. M., Shyamala, R. & Yow, Y. Y., Aug 2024, In: Journal of Applied Phycology. 36, 4, p. 2173-2182 10 p.

Research output: Contribution to journal › Article › peer-review

Transplantation of Neural Progenitor Cells Derived from Stem Cells from Apical Papilla Through Small-Molecule Induction in a Rat Model of Sciatic Nerve Injury

Koh, J., Liu, J., Poon, C. H., Kang, J., Basabrain, M. S., Lim, L. W. & Zhang, C., Aug 2024, In: Tissue Engineering and Regenerative Medicine. 21, 6, p. 867-879 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

2023

Adenosine Improves Mitochondrial Function and Biogenesis in Friedreich’s Ataxia Fibroblasts Following L-Buthionine Sulfoximine-Induced Oxidative Stress

Lew, S. Y., Mohd Hisam, N. S., Phang, M. W. L., Syed Abdul Rahman, S. N., Poh, R. Y. Y., Lim, S. H., Kamaruzzaman, M. A., Chau, S. C., Tsui, K. C., Lim, L. W. & Wong, K. H., Apr 2023, In: Biology. 12, 4, 559.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Functional MRI reveals brain-wide actions of thalamically-initiated oscillatory activities on associative memory consolidation

Wang, X., Leong, A. T. L., Tan, S. Z. K., Wong, E. C., Liu, Y., Lim, L. W. & Wu, E. X., Dec 2023, In: Nature Communications. 14, 1, 2195.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Hericium erinaceus Promotes Anti-Inflammatory Effects and Regulation of Metabolites in an Animal Model of Cerebellar Ataxia

Chau, S. C., Chong, P. S., Jin, H., Tsui, K. C., Khairuddin, S., Tse, A. C. K., Lew, S. Y., Tipoe, G. L., Lee, C. W., Fung, M. L., Wong, K. H. & Lim, L. W., Apr 2023, In: International Journal of Molecular Sciences. 24, 7, 6089.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Learning bias predicts fear acquisition under stress but not cognitive flexibility

Caudwell, K. M., Baldini, S., Calvezzi, G., Graham, A., Jackson, K., Johansson, I., Sines, M., Lim, L. W. & Aquili, L., 1 Dec 2023, In: Physiology and Behavior. 272, 114384.

Research output: Contribution to journal › Article › peer-review

Open Access

Malaysian brown macroalga Padina australis mitigates lipopolysaccharide-stimulated neuroinflammation in BV2 microglial cells

Subermaniam, K., Lew, S. Y., Yow, Y. Y., Lim, S. H., Yu, W. S., Lim, L. W. & Wong, K. H., Jun 2023, In: Iranian Journal of Basic Medical Sciences. 26, 6, p. 669-679 11 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's disease

Li, S., Poon, C. H., Zhang, Z., Yue, M., Chen, R., Zhang, Y., Hossain, M. F., Pan, Y., Zhao, J., Rong, L., Chu, L. W., Shea, Y. F., Rogaeva, E., Tu, J., St George-Hyslop, P., Lim, L. W. & Song, Y. Q., Jul 2023, In: CNS Neuroscience and Therapeutics. 29, 7, p. 1848-1864 17 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Molecular signature of excessive female aggression: study of stressed mice with genetic inactivation of neuronal serotonin synthesis

Strekalova, T., Moskvin, O., Jain, A. Y., Gorbunov, N., Gorlova, A., Sadovnik, D., Umriukhin, A., Cespuglio, R., Yu, W. S., Tse, A. C. K., Kalueff, A. V., Lesch, K. P. & Lim, L. W., Sept 2023, In: Journal of Neural Transmission. 130, 9, p. 1113-1132 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Prelimbic Cortical Stimulation Induces Antidepressant-like Responses through Dopaminergic-Dependent and -Independent Mechanisms

Khairuddin, S., Lim, W. L., Aquili, L., Tsui, K. C., Tse, A. C. K., Jayalath, S., Varma, R., Sharp, T., Benazzouz, A., Steinbusch, H., Blokland, A., Temel, Y. & Lim, L. W., Jun 2023, In: Cells. 12, 11, 1449.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Prelimbic Cortical Stimulation with L-methionine Enhances Cognition through Hippocampal DNA Methylation and Neuroplasticity Mechanisms

Poon, C. H., Liu, Y., Pak, S., Zhao, R. C., Aquili, L., Tipoe, G. L., Leung, G. K. K., Chan, Y. S., Yang, S., Fung, M. L., Wu, E. X. & Lim, L. W., 1 Feb 2023, In: Aging and Disease. 14, 1, p. 112-135 24 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Sex Differences between Neuronal Loss and the Early Onset of Amyloid Deposits and Behavioral Consequences in 5xFAD Transgenic Mouse as a Model for Alzheimer’s Disease

Poon, C. H., Wong, S. T. N., Roy, J., Wang, Y., Chan, H. W. H., Steinbusch, H., Blokland, A., Temel, Y., Aquili, L. & Lim, L. W., Mar 2023, In: Cells. 12, 5, 780.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Citations (Scopus)

2022

Altered synaptic plasticity of the longitudinal dentate gyrus network in noise-induced anxiety

Pak, S., Choi, G., Roy, J., Poon, C. H., Lee, J., Cho, D., Lee, M., Lim, L. W., Bao, S., Yang, S. & Yang, S., 17 Jun 2022, In: iScience. 25, 6, 104364.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

Antidepressant-like effects of transcorneal electrical stimulation in rat models

Yu, W. S., Tse, A. C. K., Guan, L., Chiu, J. L. Y., Tan, S. Z. K., Khairuddin, S., Agadagba, S. K., Lo, A. C. Y., Fung, M. L., Chan, Y. S., Chan, L. L. H. & Lim, L. W., 1 May 2022, In: Brain Stimulation. 15, 3, p. 843-856 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Citations (Scopus)

Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer’s disease

Tsui, K. C., Roy, J., Chau, S. C., Wong, K. H., Shi, L., Poon, C. H., Wang, Y., Strekalova, T., Aquili, L., Chang, R. C. C., Fung, M. L., Song, Y. Q. & Lim, L. W., 28 Jul 2022, In: Frontiers in Aging Neuroscience. 14, 964336.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Citations (Scopus)

How have COVID-19 stringency measures changed scholarly activity?

Caudwell, K. M., Soranzo, A., Lim, L. W. & Aquili, L., Jul 2022, In: Annals of the New York Academy of Sciences. 1513, 1, p. 5-9 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Predation Stress Causes Excessive Aggression in Female Mice with Partial Genetic Inactivation of Tryptophan Hydroxylase-2: Evidence for Altered Myelination-Related Processes

Svirin, E., Veniaminova, E., Costa-Nunes, J. P., Gorlova, A., Umriukhin, A., Kalueff, A. V., Proshin, A., Anthony, D., Nedorubov, A., Tse, A. C. K., Walitza, S., Lim, L. W., Lesch, K. P. & Strekalova, T., 18 Mar 2022, In: Cells. 11, 6, 1036.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Tetratricopeptide repeat domain 9A knockout induces social anxiety and impairs offense behaviors in female mice

Yu, W. S., Guan, L., Tan, S. Z. K., Shrestha, S., Or, Y. Z., Lufkin, T., Lin, V. C. L. & Lim, L. W., Jun 2022, In: Iranian Journal of Basic Medical Sciences. 25, 6, p. 698-703 6 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models

Yu, W. S., Aquili, L., Wong, K. H., Lo, A. C. Y., Chan, L. L. H., Chan, Y. S. & Lim, L. W., Sept 2022, In: Annals of the New York Academy of Sciences. 1515, 1, p. 249-265 17 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

2021

A Brief Comparative Look at Experimental Memory Editing Techniques for Cognitive Dysfunction

Poon, C. H., Tan, S. Z. K., Sheng, V., Wang, S., Aquili, L. & Lim, L. W., Sept 2021, In: Current Alzheimer Research. 18, 10, p. 841-848 8 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

An existentialist approach to authentic science

Tan, S. Z. K. & Lim, L. W., Dec 2021, In: IBRO Neuroscience Reports. 11, p. 52-55 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

ASD-like behaviors, a dysregulated inflammatory response and decreased expression of PLP1 characterize mice deficient for sialyltransferase ST3GAL5

Strekalova, T., Svirin, E., Veniaminova, E., Kopeikina, E., Veremeyko, T., Yung, A. W. Y., Proshin, A., Walitza, S., Anthony, D. C., Lim, L. W., Lesch, K. P. & Ponomarev, E. D., Oct 2021, In: Brain, Behavior, and Immunity - Health. 16, 100306.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Citations (Scopus)

Development of a tool to accurately predict UK REF funding allocation

Al-Janabi, S., Lim, L. W. & Aquili, L., Sept 2021, In: Scientometrics. 126, 9, p. 8049-8062 14 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Gaba supplementation negatively affects cognitive flexibility independent of tyrosine

Lim, L. W. & Aquili, L., 1 May 2021, In: Journal of Clinical Medicine. 10, 9, 1807.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms

Zhu, R., Yan, T., Feng, Y., Liu, Y., Cao, H., Peng, G., Yang, Y., Xu, Z., Liu, J., Hou, W., Wang, X., Li, Z., Deng, L., Wang, S., Li, J., Han, Q., Li, H., Shan, G., Cao, Y., An, X., & 32 othersYan, J., Zhang, Z., Li, H., Qu, X., Zhu, J., Zhou, S., Wang, J., Zhang, F., Gao, J., Jin, R., Xu, D., Ma, Y. Q., Huang, T., Peng, S., Zheng, Z., Stambler, I., Gilson, E., Lim, L. W., Moskalev, A., Cano, A., Chakrabarti, S., Ulfhake, B., Su, H., Xu, H., Xu, S., Wei, F., Brown-Borg, H. M., Min, K. J., Ellison-Hughes, G., Caruso, C., Jin, K. & Zhao, R. C., Dec 2021, In: Cell Research. 31, 12, p. 1244-1262 19 p.

Research output: Contribution to journal › Article › peer-review

96 Citations (Scopus)

Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression

Chong, P. S., Poon, C. H., Roy, J., Tsui, K. C., Lew, S. Y., Phang, M. W. L., Tan, R. J. Y., Cheng, P. G., Fung, M. L., Wong, K. H. & Lim, L. W., Dec 2021, In: Chinese Medicine (United Kingdom). 16, 1, 132.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Citations (Scopus)

Prelimbic cortical stimulation disrupts fear memory consolidation through ventral hippocampal dopamine D₂ receptors

Tan, S. Z. K., Poon, C. H., Chan, Y. S. & Lim, L. W., Sept 2021, In: British Journal of Pharmacology. 178, 17, p. 3587-3601 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

Sex-specific adhd-like behaviour, altered metabolic functions and altered eeg activity in sialyltransferase st3gal5-deficient mice

Strekalova, T., Veniaminova, E., Svirin, E., Kopeikina, E., Veremeyko, T., Yung, A. W. Y., Proshin, A., Tan, S. Z. K., Khairuddin, S., Lim, L. W., Lesch, K. P., Walitza, S., Anthony, D. C. & Ponomarev, E. D., Dec 2021, In: Biomolecules. 11, 12, 1759.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

2020

Antioxidant-mediated protective role of hericium erinaceus (Bull.: Fr.) pers. against oxidative damage in fibroblasts from friedreich’s ataxia patient

Lew, S. Y., Yow, Y. Y., Lim, L. W. & Wong, K. H., Jun 2020, In: Food Science and Technology (Brazil). 40, p. 264-272 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Citations (Scopus)

Behavioural responses of anxiety in aversive and non-aversive conditions between young and aged Sprague-Dawley rats

Hiew, L. F., Khairuddin, S., Aquili, L., Koh, J., Fung, M. L., Lim, W. L. & Lim, L. W., 15 May 2020, In: Behavioural Brain Research. 385, 112559.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Dopamine depletion effects on cognitive flexibility as modulated by tDCS of the dlPFC

Borwick, C., Lal, R., Lim, L. W., Stagg, C. J. & Aquili, L., 1 Jan 2020, In: Brain Stimulation. 13, 1, p. 105-108 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Citations (Scopus)

Dropout in Neural Networks Simulates the Paradoxical Effects of Deep Brain Stimulation on Memory

Tan, S. Z. K., Du, R., Perucho, J. A. U., Chopra, S. S., Vardhanabhuti, V. & Lim, L. W., 14 Sept 2020, In: Frontiers in Aging Neuroscience. 12, 273.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

Hericium erinaceus potentially rescues behavioural motor deficits through ERK-CREB-PSD95 neuroprotective mechanisms in rat model of 3-acetylpyridine-induced cerebellar ataxia

Chong, P. S., Khairuddin, S., Tse, A. C. K., Hiew, L. F., Lau, C. L., Tipoe, G. L., Fung, M. L., Wong, K. H. & Lim, L. W., 1 Dec 2020, In: Scientific Reports. 10, 1, 14945.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Citations (Scopus)

Neuroprotective effects of Hericium erinaceus (Bull.: Fr.) Pers. against high-dose corticosterone-induced oxidative stress in PC-12 cells

Lew, S. Y., Lim, S. H., Lim, L. W. & Wong, K. H., Dec 2020, In: BMC Complementary Medicine and Therapies. 20, 1, 340.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Citations (Scopus)

Prelimbic Cortical Stimulation Improves Spatial Memory Through Distinct Patterns of Hippocampal Gene Expression in Aged Rats

Tan, S. Z. K., Neoh, J., Lawrence, A. J., Wu, E. X. & Lim, L. W., Oct 2020, In: Neurotherapeutics. 17, 4, p. 2054-2068 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

Serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation

Tan, S. Z. K., Temel, Y., Chan, A. Y., Mok, A. T. C., Perucho, J. A. U., Blokland, A., Aquili, L., Lim, W. L. & Lim, L. W., 1 Sept 2020, In: Brain Structure and Function. 225, 7, p. 1957-1966 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Transplantation of ACE2^- Mesenchymal stem cells improves the outcome of patients with covid-19 pneumonia

Leng, Z., Zhu, R., Hou, W., Feng, Y., Yang, Y., Han, Q., Shan, G., Meng, F., Du, D., Wang, S., Fan, J., Wang, W., Deng, L., Shi, H., Li, H., Hu, Z., Zhang, F., Gao, J., Liu, H., Li, X., & 18 othersZhao, Y., Yin, K., He, X., Gao, Z., Wang, Y., Yang, B., Jin, R., Stambler, I., Lim, L. W., Su, H., Moskalev, A., Cano, A., Chakrabarti, S., Min, K. J., Ellison-Hughes, G., Caruso, C., Jin, K. & Zhao, R. C., 2020, In: Aging and Disease. 11, 2, p. 216-228 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

962 Citations (Scopus)

TTC9A deficiency induces estradiol-mediated changes in hippocampus and amygdala neuroplasticity-related gene expressions in female mice

Guan, L., Yu, W. S., Shrestha, S., Or, Y. Z., Lufkin, T., Chan, Y. S., Lin, V. C. L. & Lim, L. W., Apr 2020, In: Brain Research Bulletin. 157, p. 162-168 7 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Tyrosine negatively affects flexible-like behaviour under cognitively demanding conditions

Robson, A., Lim, L. W. & Aquili, L., 1 Jan 2020, In: Journal of Affective Disorders. 260, p. 329-333 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

2019

Catecholaminergic modulation of indices of cognitive flexibility: A pharmaco-tDCS study

Dennison, O., Gao, J., Lim, L. W., Stagg, C. J. & Aquili, L., 1 Mar 2019, In: Brain Stimulation. 12, 2, p. 290-295 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

Distribution of neuronal nitric oxide synthase immunoreactivity in adult male Sprague-Dawley rat brain

Chong, P. S., Poon, C. H., Fung, M. L., Guan, L., Steinbusch, H. W. M., Chan, Y. S., Lim, W. L. & Lim, L. W., Nov 2019, In: Acta Histochemica. 121, 8, 151437.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Lee Wei Lim

Research output

Search results