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Xin Liu

Assistant Professor

Calculated based on number of publications stored in Pure and citations from Scopus
20082024

Research activity per year

Personal profile

Personal profile

Dr. Xin Liu received her bachelor degree in Bioinformatics from Tongji University in 2007. She received her PhD degree in bioinformatics and drug design from National University of Singapore in Feb 2013. She joined Xi’an Jiaotong-Liverpool University in Feb 2019 as a lecturer in bioinformatics. Her previous research centers around system biology and computer aided drug design. Her systems analysis of cross-talks between signaling pathways promises to facilitate, at the systems level, the understanding of mechanisms of biological processes, diseases and enhanced therapeutic efficacies of multi-targeting drugs and drug combinations. She also developed a machine learning based quantitative structure-activity relationship (QSAR) method which extended the applicability of QSAR methods beyond similarity-based applicability domains (ADs). This QSAR method is capable of searching large chemical libraries for virtual hits, especially novel ones, at comparable yield and substantially improved hit rate and enrichment factor in comparison with an established method. She has published 10 peer-reviewed papers in such top journals in the field of medicinal chemistry as Current Medicinal Chemistry, PNAS and Nucleic Acids Research.Before joining XJTLU, Dr. Liu worked in industry for 6 years devoting to the exploration of molecular mechanisms of human diseases and biomarker identification by multi-omics methods and data mining.

Research interests

Systems analysis of cross-talks between pathways facilitating systems level understanding human diseases and drug target identification

Development of machine learning based quantitative structure-activity relationship (QSAR) method for high throughput screening of novel drug hits

Biomarker discovery by high throughput –omics data mining by incorporating consensus scoring of multiple random sampling and multistep evaluation of gene-ranking consistency for maximally avoiding erroneous elimination of predictor genes

Experience

Assistant Professor, Department of Biological Sciences, Xi’an Jiaotong-Liverpool University - 2019 to Present

Bioinformatics Department Manager, Shanghai Genechem Co.,Ltd. - 2016 to 2019

Bioinformatics Team Leader, Shanghai Applied Protein Technology Co., Ltd. - 2013 to 2016

Teaching

Bioinformatics I - BIO211

Practical Bioinformatics – BIO206

High-Throughput Approaches and Systems Biology – BIO316

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Ph.D, National University of Singapore, 2013

B.Eng, Tongji University, 2007

Person Types

  • Staff

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