Projects per year
Personal profile
Personal profile
Dr. Xin Liu received her bachelor degree in Bioinformatics from Tongji University in 2007. She received her PhD degree in bioinformatics and drug design from National University of Singapore in Feb 2013. She joined Xi’an Jiaotong-Liverpool University in Feb 2019 as a lecturer in bioinformatics. Her previous research centers around system biology and computer aided drug design. Her systems analysis of cross-talks between signaling pathways promises to facilitate, at the systems level, the understanding of mechanisms of biological processes, diseases and enhanced therapeutic efficacies of multi-targeting drugs and drug combinations. She also developed a machine learning based quantitative structure-activity relationship (QSAR) method which extended the applicability of QSAR methods beyond similarity-based applicability domains (ADs). This QSAR method is capable of searching large chemical libraries for virtual hits, especially novel ones, at comparable yield and substantially improved hit rate and enrichment factor in comparison with an established method. She has published 10 peer-reviewed papers in such top journals in the field of medicinal chemistry as Current Medicinal Chemistry, PNAS and Nucleic Acids Research.Before joining XJTLU, Dr. Liu worked in industry for 6 years devoting to the exploration of molecular mechanisms of human diseases and biomarker identification by multi-omics methods and data mining.
Research interests
Systems analysis of cross-talks between pathways facilitating systems level understanding human diseases and drug target identification
Development of machine learning based quantitative structure-activity relationship (QSAR) method for high throughput screening of novel drug hits
Biomarker discovery by high throughput –omics data mining by incorporating consensus scoring of multiple random sampling and multistep evaluation of gene-ranking consistency for maximally avoiding erroneous elimination of predictor genes
Experience
Assistant Professor, Department of Biological Sciences, Xi’an Jiaotong-Liverpool University - 2019 to Present
Bioinformatics Department Manager, Shanghai Genechem Co.,Ltd. - 2016 to 2019
Bioinformatics Team Leader, Shanghai Applied Protein Technology Co., Ltd. - 2013 to 2016
Teaching
Bioinformatics I - BIO211
Practical Bioinformatics – BIO206
High-Throughput Approaches and Systems Biology – BIO316
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Ph.D, National University of Singapore, 2013
B.Eng, Tongji University, 2007
Person Types
- Staff
Fingerprint
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Collaborations and top research areas from the last five years
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Research on mitigating cold-protein problem in deep learning-based drug hits virtual screening models
Huang, D., Liu, X., Li, T., Hao, Y., Wang, T., Zha, H., Li, B. & Chen, Y.
1/09/23 → 31/08/26
Project: Governmental Research Project
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Developing a protein/pocket structure-aware deep learning approach for virtual screening and de novo drug design
1/01/23 → 31/12/25
Project: Internal Research Project
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SIP High-quality Innovation Platform for chronic diseases
Fu, L., Zhang, X., Liu, X., Wang, R., Li, Y., Gu, J., Ruan, G., Chen, J., Zhang, J., Lee, M. H., Wang, Y., Chen, Y., Guo, J., Wang, Y., Hong, M., Yue, Y., Guo, H., Xu, H., Yang, D. & Cheng, J.
1/09/22 → 30/08/25
Project: Governmental Research Project
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A machine learning based method for virtual screening and optimization in multi-target drug discovery
Liu, X., Hao, Y., Wang, T., Li, T., Li, J. & Chen, Y.
1/07/20 → 30/06/24
Project: Governmental Research Project
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A Graph Convolution-Transformer Neural Network for Drug-Target Interaction Prediction
Wang, T. & Liu, X., 27 May 2022, ICBBT 2022 - Proceedings of 2022 14th International Conference on Bioinformatics and Biomedical Technology. Association for Computing Machinery, p. 145-150 6 p. (ACM International Conference Proceeding Series).Research output: Chapter in Book or Report/Conference proceeding › Conference Proceeding › peer-review
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Comparing Bayesian‐Based Reconstruction Strategies in Topology‐Based Pathway Enrichment Analysis
Wang, Y., Li, J., Huang, D., Hao, Y., Li, B., Wang, K., Chen, B., Li, T. & Liu, X., Jul 2022, In: Biomolecules. 12, 7, 906.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Developing A Multi-task Edge-attention based Graph Deep Learning Algorithm for Kinase Polypharmacology Profiling
Zha, H., Hao, Y. & Liu, X., 27 May 2022, ICBBT 2022 - Proceedings of 2022 14th International Conference on Bioinformatics and Biomedical Technology. Association for Computing Machinery, p. 125-129 5 p. (ACM International Conference Proceeding Series).Research output: Chapter in Book or Report/Conference proceeding › Conference Proceeding › peer-review
1 Citation (Scopus) -
Discovery of Stomach Adenocarcinoma Biomarkers by Consensus Scoring of Random Sampling and Machine Learning Modeling
Chen, J., Hao, Y., Wang, T., Huang, D. & Liu, X., 2022, 2022 10th International Conference on Bioinformatics and Computational Biology, ICBCB 2022. Institute of Electrical and Electronics Engineers Inc., p. 112-115 4 p. (2022 10th International Conference on Bioinformatics and Computational Biology, ICBCB 2022).Research output: Chapter in Book or Report/Conference proceeding › Conference Proceeding › peer-review
1 Citation (Scopus) -
Towards cheminformatics-based estimation of drug therapeutic index: Predicting the protective index of anticonvulsants using a new quantitative structure-index relationship approach
Chen, S., Zhang, P., Liu, X., Qin, C., Tao, L., Zhang, C., Yang, S. Y., Chen, Y. Z. & Chui, W. K., 1 Jun 2016, In: Journal of Molecular Graphics and Modelling. 67, p. 102-110 9 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)
Activities
- 1 Editorial work
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Journal of Cellular Biochemistry (Journal)
Xin Liu (Member of editorial board)
2020 → …Activity: Peer-review and editorial work of publications › Editorial work