Projects per year
Personal profile
Personal profile
Dr. Song joined the Academy of Pharmacy, Xi’an Jiaotong-Liverpool University as an Assistant Professor in Jan 2024. She received her PhD in 2018 under the mentorship of Dr. Richard Mortensen at the University of Michigan, Ann Arbor, Department of Cell and Developmental Biology. Her postdoctoral work was conducted in the Department of Internal Medicine with Dr. Daniel Goldstein. She gained her expertise in aging, immunity, adipose tissue, cardiovascular diseases (CVDs) and cancer. Her laboratory is interested in how aging impacts immunity and immune cell metabolism in disease models including CVDs, cancer and obesity. Mechanistically, their work focuses on immunity, inflammation, aging, metabolism, adipose tissue and autophagy.
Research interests
1. Obesity promotes cancer development and progression during aging.
2. How itaconate suppresses inflammation to improve cardiovascular diseases.
3. Activate immunity through autophagy to fight against cancer with age.
4. Immune cell metabolism reprogramming in disease models like cardiovascular diseases and cancer.
Experience
Postdoctoral Research Fellow, University of Michigan, Ann Arbor USA 2018-2023
Research Assistant, Eastern Hepatobiliary Surgery Hospital, Shanghai China 2009-2012
Teaching
APH218 Principles of Pharmacology
APH202 Pharmacology
Awards and honours
3rd Prize of Jiangsu Science and Technology Award, Jiangsu Provincial Peoples Government
2nd Prize of Shanghai Science and Technology Award, The Shanghai Municipal Peoples Government
The Ming K.Jeang scholarship Award, Society of Chinese Bioscientists in America
Employee of the Year, Eastern Hepatobiliary Surgery Hospital
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Related documents
Age-associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis
Age and Sex: Impact on adipose tissue metabolism and inflammation
Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis
Aconitate decarboxylase 1 regulates glucose homeostasis and obesity in mice
Education/Academic qualification
Ph.D, Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA 2012-2018
MMed, Oncology, Second Military Medical University, Shanghai China 2006-2009
Person Types
- Staff
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 2 Active
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Jiangsu Province Higher Education Key Laboratory of Cell Therapy Nanoformulation (Construction)
Ruan, G., Lee, M. H., Wu, Q., Lu, T., Xu, P., Loo, S., Sun, Y., Kam, A., Liu, X., Wen, X., Zhang, J., Wang, M., Xu, M., Cheng, K., Zhang, X., Song, J., Guo, B., Wang, Y., Wang, J., Wu, S., Yang, J., Fu, L., Zhang, J., Qiao, Y., Chen, Y., Li, T., Gu, J., Zhan, T., Wan, Y., He, Z., Cheng, Y., Leng, J., Qi, M., Ho, J., Sun, Y., Zhang, N., Soe, H. M. S. H., Ling, C., Zhou, H. & Huang, D.
1/07/24 → 30/06/27
Project: Governmental Research Project
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Mechanistic investigation about the anti-inflammatory role of itaconate in atherosclerosis
1/07/24 → 30/06/27
Project: Internal Research Project
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Analysis of PD-1/PD-L1 variations in lung cancer and association with immunotherapeutic efficacy and prognosis: A nonrandomized controlled trial
Ma, J., Song, J. R., Han, L. N., Zhou, W., Meng, L. F., Li, J. H. & Bai, X. M., 1 Jan 2024, In: Clinics. 79, 100395.Research output: Contribution to journal › Article › peer-review
Open Access -
Endosomal protein DENND10/FAM45A integrates extracellular vesicle release with cancer cell migration.
Sun, S., Li, Q., Liu, G., Huang, X., Li, A., Guo, H., Qi, L., Zhang, J., Song, J., Su, X. & Zhang, Y., Jul 2024, In: BMC Biology. 22, 1Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice
Song, J., Zhang, Y., Frieler, R. A., Andren, A., Wood, S., Tyrrell, D. J., Sajjakulnukit, P., Deng, J. C., Lyssiotis, C. A., Mortensen, R. M., Salmon, M. & Goldstein, D. R., 10 Feb 2024, In: Journal of Clinical Investigation. 134, 3, e173034.Research output: Contribution to journal › Article › peer-review
Open Access -
Publisher Correction: Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice(Nature Aging, 10.1038/s43587-023-00515-w)
Tyrrell, D. J., Wragg, K. M., Chen, J., Wang, H., Song, J., Blin, M. G., Bolding, C., Vardaman, D., Giles, K., Tidwell, H., Ali, M. A., Janappareddi, A., Wood, S. C. & Goldstein, D. R., Aug 2024, In: Nature Aging. 4, 8, p. 1166 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Age-associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis
Song, J., Farris, D., Ariza, P., Moorjani, S., Varghese, M., Blin, M., Chen, J., Tyrrell, D., Zhang, M., Singer, K., Salmon, M. & Goldstein, D. R., Feb 2023, In: Aging Cell. 22, 2, e13783.Research output: Contribution to journal › Article › peer-review
Open Access
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Bioactive Materials (Journal)
Jianrui Song (Reviewer)
2025Activity: Peer-review and editorial work of publications › Editorial work
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Itaconate suppresses atherosclerosis by activating anti-inflammatory response in macrophages
Jianrui Song (Speaker)
27 Oct 2024Activity: Talk or presentation › Presentation at conference/workshop/seminar
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Aging Cell (Journal)
Jianrui Song (Reviewer)
2023Activity: Peer-review and editorial work of publications › Editorial work
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Cell Death and Disease (Journal)
Jianrui Song (Reviewer)
2016 → 2025Activity: Peer-review and editorial work of publications › Editorial work