Meng Huee Lee

Research output

Research output per year 1995 1996 2002 2003 2004 2010 2015 2022 2023

• 41 Article
• 2 Patent
• 1 Comment/debate

Research output per year

Research output per year

Search results

• 2022

  Complete abrogation of key osteoclast markers with a membrane-anchored tissue inhibitor of metalloproteinase

  Zhang, Y., Jiang, B., Zhang, P., Chiu, S. K. & Lee, M. H., Nov 2022, In: Bone and Joint Research. 11, 11, p. 763-776 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Metalloprotease Inhibitor 100%
  • Osteoclast 100%
  • Membrane 100%
  • Tissue Inhibitor of Metalloproteinase 100%
  • Receptor 40%
  3 Citations (Scopus)

• Complete abrogation of key osteoclast markers with a membrane-anchored tissue inhibitor of metalloproteinase: A NOVEL APPROACH IN THE PREVENTION OF OSTEOCLASTOGENESIS

  Lee, M. H., Zhang, Y., Jiang, B., Zhang, P. & Chiu, S. K., Oct 2022, (Accepted/In press) In: Bone and Joint Research. 11, 10, 14 p., doi: 10.1302/2046-3758.1110.BJR2022-0147.R2.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  25 Downloads (Pure)

• Modulation of peritumoral fibroblasts with a membrane-tethered tissue inhibitor of metalloproteinase (TIMP) for the elimination of cancer cells

  Zhang, Y., Liu, S., Jiang, B., Chiu, S. K. & Lee, M. H., Feb 2022, In: Investigational New Drugs. 40, 1, p. 198-208 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2020

  A novel 3d model for visualization and tracking of fibroblast-guided directional cancer cell migration

  Zhang, Y., Jiang, B. & Lee, M. H., Oct 2020, In: Biology. 9, 10, p. 1-13 13 p., 328.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Citations (Scopus)
• 2019

  Targeting a designer TIMP-1 to the cell surface for effective MT1-MMP inhibition: A potential role for the prion protein in renal carcinoma therapy

  Jiang, B., Liu, J. & Lee, M. H., 11 Jan 2019, In: Molecules. 24, 2, 255.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Surface Property 100%
  • Tissue Inhibitor of Metalloproteinase 100%
  • Membrane-Type Matrix Metalloproteinase-1 100%
  • Prion 100%
  • Phosphatidylinositol 37%
  13 Citations (Scopus)

• Translocating a high-affinity designer TIMP-1 to the cell membrane for total renal carcinoma inhibition: Putting the prion protein to good use

  Jiang, B., Xu, Y., Zhang, Y. & Lee, M. H., 1 Sept 2019, In: Molecular and Cellular Biology. 39, 18, e00128-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  4 Citations (Scopus)
• 2017

  Ensnaring membrane type 1-matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase (TIMP)-2 using the haemopexin domain of the protease as a carrier: A targeted approach in cancer inhibition

  Jiang, B., Zhang, Y., Liu, J., Tsigkou, A., Rapti, M. & Lee, M. H., 2017, In: Oncotarget. 8, 14, p. 22685-22699 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  5 Citations (Scopus)
• 2016

  ADAMTS13 and 15 are not regulated by the full length and N-terminal domain forms of TIMP-1, -2, -3 and -4

  Guo, C., Tsigkou, A. & Lee, M. H., 1 Jan 2016, In: Biomedical Reports. 4, 1, p. 73-78 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ADAMTS13 100%
  • A Disintegrin and Metalloproteinase 75%
  • Von Willebrand Factor 25%
  8 Citations (Scopus)
• 2015

  Expanding the activity of Tissue Inhibitors of Metalloproteinase (TIMP)-1 against surface-anchored metalloproteinases by the replacement of its C-terminal domain: Implications for anti-cancer effects

  Duan, J. X., Rapti, M., Tsigkou, A. & Lee, M. H., 26 Aug 2015, In: PLoS ONE. 10, 8, e0136384.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  13 Citations (Scopus)

• Expression Levels of Myostatin and Matrix Metalloproteinase 14 mRNAs in Uterine Leiomyoma are Correlated with Dysmenorrhea

  Tsigkou, A., Reis, F. M., Ciarmela, P., Lee, M. H., Jiang, B., Tosti, C., Shen, F. R., Shi, Z., Chen, Y. G. & Petraglia, F., 1 Dec 2015, In: Reproductive Sciences. 22, 12, p. 1597-1602 6 p.

  Research output: Contribution to journal › Article › peer-review
  20 Citations (Scopus)

• Increased progesterone receptor expression in uterine leiomyoma: Correlation with age, number of leiomyomas, and clinical symptoms

  Tsigkou, A., Reis, F. M., Lee, M. H., Jiang, B., Tosti, C., Centini, G., Shen, F. R., Chen, Y. G. & Petraglia, F., 1 Jul 2015, In: Fertility and Sterility. 104, 1, p. 170-175.e1

  Research output: Contribution to journal › Article › peer-review

  Open Access
  45 Citations (Scopus)
• 2012

  Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex

  Troeberg, L., Mulloy, B., Ghosh, P., Lee, M. H., Murphy, G. & Nagase, H., 1 Apr 2012, In: Biochemical Journal. 443, 1, p. 307-315 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  33 Citations (Scopus)
• 2010

  A Node-to-Node Location Verification Method

  Liu, D., Lee, M. C. & Wu, D., 2010, In: IEEE Transactions on Industrial Electronics. 57, 5, p. 1526-1537 12 p.

  Research output: Contribution to journal › Article › peer-review

  38 Citations (Scopus)

• Mobility enhanced localization in outdoor environments

  Liu, D. & Lee, M. C., 2010, In: Wireless Communications and Mobile Computing. 10, 9, p. 1270-1280 11 p.

  Research output: Contribution to journal › Article › peer-review

  4 Citations (Scopus)

• Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)

  Kveiborg, M., Jacobsen, J., Meng-Huee, L., Nagase, H., Wewer, U. M. & Murphy, G., 15 Aug 2010, In: Biochemical Journal. 430, 1, p. 79-86 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  34 Citations (Scopus)

• The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment

  Lee, M. H., Atkinson, S., Rapti, M., Handsley, M., Curry, V., Edwards, D. & Murphy, G., 1 Apr 2010, In: Cancer Letters. 290, 1, p. 114-122 9 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function

  Grossman, M., Tworowski, D., Dym, O., Lee, M. H., Levy, Y., Murphy, G. & Sagi, I., 27 Jul 2010, In: Biochemistry. 49, 29, p. 6184-6192 9 p.

  Research output: Contribution to journal › Article › peer-review
  53 Citations (Scopus)
• 2009

  Analysis of Wireless Localization using Non-Line-of-Sight Radio Signals

  Liu, D. & Lee, M. C., 2009, In: in Proc. of ACM GIS.

  Research output: Contribution to journal › Article › peer-review

  1 Citation (Scopus)
• 2008

  Mobile localization in outdoor environments

  Liu, D. & Lee, M. C., 2008, In: Proceedings of the International Symposium on a World of Wireless, Mobile and Multimedia Networks (WoWMoM).

  Research output: Contribution to journal › Article › peer-review

  1 Citation (Scopus)

• The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition

  Rapti, M., Atkinson, S. J., Lee, M. H., Trim, A., Moss, M. & Murphy, G., 15 Apr 2008, In: Biochemical Journal. 411, 2, p. 433-439 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  39 Citations (Scopus)
• 2007

  Identification of the Extracellular Matrix (ECM) binding motifs of tissue inhibitor of metalloproteinases (TIMP)-3 and effective transfer to TIMP-1

  Lee, M. H., Atkinson, S. & Murphy, G., 2 Mar 2007, In: Journal of Biological Chemistry. 282, 9, p. 6887-6898 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  67 Citations (Scopus)
• 2005

  Total conversion of tissue inhibitor of metalloproteinase (TIMP) for specific metalloproteinase targeting: Fine-tuning TIMP-4 for optimal inhibition of tumor necrosis factor-α-converting enzyme

  Lee, M. H., Rapti, M. & Murphy, G., 22 Apr 2005, In: Journal of Biological Chemistry. 280, 16, p. 15967-15975 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  52 Citations (Scopus)

• What are the roles of metalloproteinases in cartilage and bone damage?

  Murphy, G. & Lee, M. H., Nov 2005, In: Annals of the Rheumatic Diseases. 64, SUPPL. 4, p. iv44-iv47

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Metalloproteinase 100%
  • Bone Injury 100%
  • Cartilage 100%
  • Bone 100%
  • Metalloproteinase Inhibitor 100%
  106 Citations (Scopus)
• 2004

  Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-α-converting enzyme

  Lee, M. H., Rapti, M. & Murphy, G., 22 Oct 2004, In: Journal of Biological Chemistry. 279, 43, p. 45121-45129 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  27 Citations (Scopus)

• Threonine 98, the Pivotal Residue of Tissue Inhibitor of Metalloproteinases (TIMP)-1 in Metalloproteinase Recognition

  Lee, M. H., Rapti, M., Knäuper, V. & Murphy, G., 23 Apr 2004, In: Journal of Biological Chemistry. 279, 17, p. 17562-17569 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tissue Inhibitor of Metalloproteinase 1 100%
  • Metalloproteinase 100%
  • Threonine 100%
  • Recognition 100%
  • Tissue Inhibitor of Metalloproteinase 100%
  53 Citations (Scopus)
• 2003

  Role of TIMPs (tissue inhibitors of metalloproteinases) in pericellular proteolysis: The specificity is in the detail

  Murphy, G., Knäuper, V., Lee, M. H., Amour, A., Worley, J. R., Hutton, M., Atkinson, S., Rapti, M. & Williamson, R., 2003, In: Biochemical Society Symposium. 70, p. 65-80 16 p.

  Research output: Contribution to journal › Article › peer-review
  64 Citations (Scopus)

• Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP)

  Worley, J. R., Thompkins, P. B., Lee, M. H., Hutton, M., Soloway, P., Edwards, D. R., Murphy, G. & Knäuper, V., 15 Jun 2003, In: Biochemical Journal. 372, 3, p. 799-809 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  55 Citations (Scopus)

• Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-α converting enzyme

  Lee, M. H., Dodds, P., Verma, V., Maskos, K., Knäuper, V. & Murphy, G., 15 Apr 2003, In: Biochemical Journal. 371, 2, p. 369-376 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  21 Citations (Scopus)

• Unveiling the surface epitopes that render tissue inhibitor of metalloproteinase-1 inactive against membrane type 1-matrix metalloproteinase

  Lee, M. H., Rapti, M. & Murphy, G., 10 Oct 2003, In: Journal of Biological Chemistry. 278, 41, p. 40224-40230 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  63 Citations (Scopus)
• 2002

  Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-α-converting enzyme

  Lee, M. H., Verma, V., Maskos, K., Nath, D., Knäuper, V., Dodds, P., Amour, A. & Murphy, G., 15 May 2002, In: Biochemical Journal. 364, 1, p. 227-234 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  47 Citations (Scopus)

• Mapping and characterization of the functional epitopes of tissue inhibitor of metalloproteinases (TIMP)-3 using TIMP-1 as the scaffold: A new frontier in timp engineering

  Lee, M. H., Maskos, K., Knäuper, V., Dodds, P. & Murphy, G., Oct 2002, In: Protein Science. 11, 10, p. 2493-2503 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  29 Citations (Scopus)

• The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3

  Lee, M. H., Verma, V., Maskos, K., Becherer, J. D., Knäuper, V., Dodds, P., Amour, A. & Murphy, G., 5 Jun 2002, In: FEBS Letters. 520, 1-3, p. 102-106 5 p.

  Research output: Contribution to journal › Article › peer-review
  33 Citations (Scopus)
• 2001

  Full-length and N-TIMP-3 display equal inhibitory activities toward TNF-α convertase

  Lee, M. H., Knäuper, V., Becherer, J. D. & Murphy, G., 15 Dec 2001, In: Biochemical and Biophysical Research Communications. 280, 3, p. 945-950 6 p.

  Research output: Contribution to journal › Article › peer-review
  52 Citations (Scopus)
• 2000

  Cloning, expression, and purification of mammalian 4-hydroxyphenylpyruvate dioxygenase/α-ketoisocaproate dioxygenase

  Crouch, N. P., Lee, M. H., Iturriagagoitia-Bueno, T. & Mackinnon, C. H., 2000, In: Methods in Enzymology. 324, p. 342-355 14 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)
• 1997

  A mechanistic rationalisation for the substrate specificity of recombinant mammalian 4-hydroxyphenylpyruvate dioxygenase (4-HPPD)

  Crouch, N. P., Adlington, R. M., Baldwin, J. E., Lee, M. H. & MacKinnon, C. H., 19 May 1997, In: Tetrahedron. 53, 20, p. 6993-7010 18 p.

  Research output: Contribution to journal › Article › peer-review
  50 Citations (Scopus)

• Stereochemical course of the conversion of α-ketoisocaproate to β-hydroxyisovalerate by soluble, recombinant mammalian 4-hydroxyphenylpyruvate dioxygenase

  Crouch, N. P., Adlington, R. M., Baldwin, J. E., Lee, M. H., MacKinnon, C. H. & Paul, D. R., 4 Aug 1997, In: Tetrahedron. 53, 31, p. 10827-10840 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Dioxygenase 100%
  • Soluble 100%
  • 4-Hydroxyphenylpyruvate Dioxygenase 100%
  • Lysozyme 50%
  6 Citations (Scopus)
• 1996

  Identification and stereochemistry of the product of 4-HPPD catalyzed oxidation of the ketoacid of methionine

  Adlington, R. M., Baldwin, J. E., Crouch, N. P., Lee, M. H. & MacKinnon, C. H., 20 Aug 1996, In: Bioorganic and Medicinal Chemistry Letters. 6, 16, p. 2003-2006 4 p.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• Initial studies on the substrate specificity of soluble recombinant 4- hydroxyphenylpyruvate dioxygenase from rat liver

  Crouch, N. P., Baldwin, J. E., Lee, M. H., MacKinnon, C. H. & Zhang, Z. H., 9 Jul 1996, In: Bioorganic and Medicinal Chemistry Letters. 6, 13, p. 1503-1506 4 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Stereochemistry of hydroxylation during the conversion of α-ketoisocaproate to β-hydroxyisovalerate by 4-hydroxyphenylpyruvate dioxygenase

  Adlington, R. M., Baldwin, J. E., Crouch, N. P., Lee, M. H., MacKinnon, C. H. & Paul, D. R., 19 Nov 1996, In: Bioorganic and Medicinal Chemistry Letters. 6, 22, p. 2721-2724 4 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• The C-terminal of rat 4-hydroxyphenylpyruvate dioxygenase is indispensable for enzyme activity

  Lee, M. H., Zhang, Z. H., MacKinnon, C. H., Baldwin, J. E. & Crouch, N. P., 16 Sept 1996, In: FEBS Letters. 393, 2-3, p. 269-272 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  21 Citations (Scopus)
• 1995

  4-Hydroxyphenylpyruvate dioxygenase appears to display α-ketoisocaproate dioxygenase activity in rat liver

  Baldwin, J. E., Crouch, N. P., Fujishima, Y., Lee, M. H., MacKinnon, C. H., Pitt, J. P. N. & Willis, A. C., 22 Jun 1995, In: Bioorganic and Medicinal Chemistry Letters. 5, 12, p. 1255-1260 6 p.

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)