Projects per year
Personal profile
Personal profile
Dr Yuewei Xu did his undergrad study in the Department of Biological Sciences at XJTLU (2013-2017) and then completed MRes (Cancer Biology) and PhD study at Imperial College London. During the PhD, his research focused on developing novel combination therapies for PARP inhibitor resistant ovarian cancer. Later, he worked in WuXi Biologics (Shanghai) for 1.5 years and led a team of four scientists. His group has helped multiple clients developing cell lines, producing biopharmaceuticals, and optimizing culture process for large scale production.
Driven by passion for teaching and research, Yuewei came back to academia. He felt studying at XJTLU was a life-changing experience and he hope more students can feel the same.
Here at XJTLU, Yuewei's research uses drug combination screens to identify novel drug combinations for cancer treatment. He is also interested in studying how alternative RNA splicing may affect cellular response to DNA damage and other stresses.
Over the years of study and reserach, Yuewei has used a range of functional assays that are very useful for cancer research, such as cell growth, apoptosis, cell cycle, DNA damage, RNA splicing, 3D cell invasion assays, and synergy analysis.
If you are interested in working with Yuewei, please feel free to send an email or visit office SD334G for a chat.
Office hours (for AY24/25-S2):
Tuesday (13:00 - 14:00) & Thursday (17:00 - 18:00)
(May be adjusted in case of time conflicts.)
Awards and honours
- 2024 Poster Award (2nd place), ZOMES meeting, Shenzhen China.
- 2018-2022 Full PhD scholarship by China Scholarship Council & Imperial College London.
- 2017 Top Project Award for BSc thesis, Royal Society of Biology, UK
- 2017 Best Performance in FYP, XJTLU, China
- 2017 Best Overall Academic Performance, XJTLU, China
- 2016 National Scholarship by the Ministry of Education, China
- 2014-2016 XJTLU scholarships (3 times)
Experience
2024.09 - present | Assistant Professor, XJTLU |
2023.02 - 2024.08 | Principal Scientist II (Elite Program), WuXi Biologics |
Teaching
APH430 Quality Assurance for Drugs and Biologics (module leader)
APH428 Quality Systems and Standards (module leader)
APH438 Advanced Pharmacotherapy (co-teaching)
Research interests
RNA splicing in cancer
Drugs (PROTACs or inhibitors) for splicing factors
Novel combination therapies and synthetic lethality
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Related documents
Education/Academic qualification
PhD, Cancer Biology, Imperial College London
7 Jan 2019 → 1 Feb 2023
Award Date: 1 Feb 2023
Master, MRes Cancer Biology (Distinction), Imperial College London
30 Sept 2017 → 30 Sept 2018
Award Date: 30 Sept 2018
Bachelor, BSc Biological Sciences (Ranked top 1), Xi'an Jiaotong-Liverpool University
1 Sept 2013 → 30 Jul 2017
Award Date: 30 Jul 2017
Keywords
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
- Cancer Biology
- DNA damage
- Apoptosis
- RNA splicing
- Molecular glue / PROTAC
- R Medicine (General)
- Drug development
Person Types
- Staff
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Collaborations and top research areas from the last five years
Projects
- 1 Active
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Targeting RNA splicing as a novel strategy to treat medulloblastoma
1/07/25 → 30/06/28
Project: Internal Research Project
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PTEN Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Spear, S., Le Saux, O., Mirza, H. B., Iyer, N., Tyson, K., Freile, F. G., Walton, J. B., Woodman, C., Jarvis, S., Ennis, D. P., Hernandez, C. A., Xu, Y., Spiliopoulou, P., Brenton, J. D., Costa-Pereira, A. P., Cook, D. P., Vanderhyden, B. C., Keun, H. C., Triantafyllou, E., Arnold, J. N., & 1 others , Nov 2024, In: Cancer Research. 84, 22, p. 3772-3787 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
Xu, Y., Spear, S., Ma, Y., Lorentzen, M. P., Gruet, M., McKinney, F., Xu, Y., Wickremesinghe, C., Shepherd, M. R., McNeish, I., Keun, H. C. & Nijhuis, A., 31 Oct 2023, In: Cell Reports. 42, 10, 113307.Research output: Contribution to journal › Article › peer-review
Open Access -
Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma
Nijhuis, A., Sikka, A., Yogev, O., Herendi, L., Balcells, C., Ma, Y., Poon, E., Eckold, C., Valbuena, G. N., Xu, Y., Liu, Y., da Costa, B. M., Gruet, M., Wickremesinghe, C., Benito, A., Kramer, H., Montoya, A., Carling, D., Want, E. J., Jamin, Y., & 2 others , Dec 2022, In: Nature Communications. 13, 1, 1380.Research output: Contribution to journal › Article › peer-review
Open Access -
RNA-binding motif protein 39 (RBM39): An emerging cancer target
Xu, Y., Nijhuis, A. & Keun, H. C., Jun 2022, In: British Journal of Pharmacology. 179, 12, p. 2795-2812 18 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
DDR1 autophosphorylation is a result of aggregation into dense clusters
Corcoran, D. S., Juskaite, V., Xu, Y., Görlitz, F., Alexandrov, Y., Dunsby, C., French, P. M. W. & Leitinger, B., 1 Dec 2019, In: Scientific Reports. 9, 1, 17104.Research output: Contribution to journal › Article › peer-review
Open Access