Projects per year
Personal profile
Personal profile
Dr. Daiyun Huang received his BSc degree in Mathematics from the University of Liverpool in 2017, his MSc degree in Statistical Science from the University of Oxford in 2018, and his Ph.D. degree in Computer Science from the University of Liverpool in July 2022. He joined the Academy of Pharmacy at XJTLU as a postdoctoral fellow in November 2022.His previous research revolved around developing deep learning models for biological sequences, especially for RNA modification research. His current research interests mainly focus on AI-aided drug discovery, including developing deep learning methods for high-throughput virtual screening and de novo generation of hit-like molecules. Special attention is paid to out-of-distribution problems and protein representation learning.
Research interests
AI-aided drug discovery: high-throughput virtual screening and de novo generation of hit-like molecules.
Prediction and engineering of non-coding sequences of mRNA-based therapeutics based on deep learning
Develop computational models of biological sequences (DNA, RNA, and proteins) to address meaningful biological questions, such as predicting the effect of mutations on protein function.
Experience
Postdoc, Academy of Pharmacy, Xian Jiaotong-Liverpool University, 2022-present
Teaching
APH101-2223-S2-Biostatistics and R Programming
APH102-2223-S2-Mathematical Modeling
Awards and honours
2022年入选“苏州市自然科学优秀学术论文一等奖”(SZLW202206,2020-2021年度)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Ph.D., University of Liverpool, 2022
MSc, University of Oxford, 2018
BSc, University of Liverpool, 2017
Person Types
- Staff
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Collaborations and top research areas from the last five years
Projects
- 2 Active
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Prediction and engineering of non-coding sequences of mRNA therapeutics based on deep learning
1/01/24 → 31/12/26
Project: Governmental Research Project
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Research on mitigating cold-protein problem in deep learning-based drug hits virtual screening models
Huang, D., Liu, X., Li, T., Hao, Y., Wang, T., Zha, H., Li, B. & Chen, Y.
1/09/23 → 31/08/26
Project: Governmental Research Project
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DirectRMDB: a database of post-transcriptional RNA modifications unveiled from direct RNA sequencing technology
Zhang, Y., Jiang, J., Ma, J., Wei, Z., Wang, Y., Song, B., Meng, J., Jia, G., De Magalhães, J. P., Rigden, D. J., Hang, D. & Chen, K., 6 Jan 2023, In: Nucleic Acids Research. 51, D1, p. D106-D116Research output: Contribution to journal › Article › peer-review
Open Access33 Citations (Scopus) -
m6A-Atlas v2.0: updated resources for unraveling the N 6-methyladenosine (m6A) epitranscriptome among multiple species.
Wei, Z., Meng, J., Wang, Y. & Huang, D., 2023, In: Nucleic Acids Research.Research output: Contribution to journal › Article › peer-review
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m6A-TSHub: Unveiling the Context-Specific m6A Methylation and m6A-Affecting Mutations in 23 Human Tissues: Unveiling the Context-specific m6A Methylation and m6A-affecting Mutations in 23 Human Tissues
Song, B., Huang, D., Zhang, Y., Wei, Z., Su, J., Pedro de Magalhães, J., Rigden, D. J., Meng, J. & Chen, K., Aug 2023, In: Genomics, Proteomics and Bioinformatics. 21, 4, p. 678-694 17 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Citations (Scopus) -
Multi-task adaptive pooling enabled synergetic learning of RNA modification across tissue, type and species from low-resolution epitranscriptomes
Song, Y., Wang, Y., Wang, X., Huang, D., Nguyen, A. & Meng, J., 1 May 2023, In: Briefings in Bioinformatics. 24, 3, bbad105.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
RMDisease V2.0: an updated database of genetic variants that affect RNA modifications with disease and trait implication
Song, B., Wang, X., Liang, Z., Ma, J., Huang, D., Wang, Y., de Magalhães, J. P., Rigden, D. J., Meng, J., Liu, G., Chen, K. & Wei, Z., 6 Jan 2023, In: Nucleic Acids Research. 51, D1, p. D1388-D1396Research output: Contribution to journal › Article › peer-review
Open Access20 Citations (Scopus)