Src family kinases in the central nervous system: Their emerging role in pathophysiology of migraine and neuropathic pain

Lingdi Nie, Wen Rui Ye, Shangbin Chen, Domenico Chirchiglia, Minyan Wang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Src family kinases (SFK) are a group of non-receptor tyrosine kinases which play a pivotal role in cellular responses and oncogenesis. Accumulating evidence suggest that SFK also act as a key component in signalling pathways of the central nervous system (CNS) in both physiological and pathological conditions. Despite the crucial role of SFK in signal transduction of the CNS, the relationship between SFK and molecules implicated in pain has been relatively unexplored. This ar-ticle briefly reviews the recent advances uncovering the interplay of SFK with diverse membrane proteins and intracellular proteins in the CNS and the importance of SFK in the pathophysiology of migraine and neuropathic pain. Mechanisms underlying the role of SFK in these conditions and potential clinical applications of SFK inhibitors in neurological diseases are also summarised. We pro-pose that SFK are the convergent point of signalling pathways in migraine and neuropathic pain and may constitute a promising therapeutic target for these diseases.

Original languageEnglish
Pages (from-to)665-678
Number of pages14
JournalCurrent Neuropharmacology
Volume19
Issue number5
DOIs
Publication statusPublished - 2021

Keywords

  • Migraine
  • NMDA receptors
  • Neuroinflammation
  • Neuropathic pain
  • P2X receptors
  • Src family kinase

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