Lipid extraction by boron nitride nanosheets from liquid-ordered and liquid-disordered nanodomains

Yonghui Zhang, Chun Chan, Zhen Li, Jiale Ma, Qiangqiang Meng, Xiaolin Cheng, Jun Fan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Atomically thin boron nitride nanosheets are important two-dimensional nanomaterials with great potential in biomedical applications. Understanding the basic interaction mechanisms between lipid domains and boron nitride nanosheets can help clarify the potential risks of these nanomaterials and thus provide guidance on the design of safe biomedical applications. Using molecular dynamics simulations, we demonstrate that the BNNS can disrupt the liquid disordered lipid bilayers much more easily compared to the liquid ordered phases. The potential of mean force profiles calculated from umbrella sampling further explain this adsorption preference. When the BNNS is placed at the boundary of the liquid ordered and liquid disordered nanodomains, disruption of the liquid ordered domains becomes much easier due to the presence of adjacent liquid disordered domains. Our findings provide new insights into the cytotoxicity of boron nitride nanosheets interacting with cellular membranes.

Original languageEnglish
Pages (from-to)14073-14081
Number of pages9
Issue number29
Publication statusPublished - 7 Aug 2018
Externally publishedYes


Dive into the research topics of 'Lipid extraction by boron nitride nanosheets from liquid-ordered and liquid-disordered nanodomains'. Together they form a unique fingerprint.

Cite this