TY - JOUR
T1 - Deep brain stimulation of the nucleus accumbens core and shell
T2 - Opposite effects on impulsive action
AU - Sesia, Thibaut
AU - Temel, Yasin
AU - Lim, Lee Wei
AU - Blokland, Arjan
AU - Steinbusch, Harry W.M.
AU - Visser-Vandewalle, Veerle
PY - 2008/11
Y1 - 2008/11
N2 - The nucleus accumbens is gaining interest as a target for deep brain stimulation in refractory neuropsychiatric disorders with impulsivity as core symptom. The nucleus accumbens is composed of two subterritories, core and shell, which have different anatomical connections. Here, we tested the hypothesis that stimulation of the nucleus accumbens core and shell would have different effects on impulsivity. Rats received bilateral stimulation at the level of the nucleus accumbens core or shell during a reaction time task. Stimulation of the nucleus accumbens core significantly decreased impulsivity, while stimulation of the shell increased it. Our results support the hypothesis that the nucleus accumbens is a potential target to treat neuropsychiatric disorders related to impulsivity by deep brain stimulation. However, different behavioral effects resulting from stimulation of the subterritories should be taken into account. Crown
AB - The nucleus accumbens is gaining interest as a target for deep brain stimulation in refractory neuropsychiatric disorders with impulsivity as core symptom. The nucleus accumbens is composed of two subterritories, core and shell, which have different anatomical connections. Here, we tested the hypothesis that stimulation of the nucleus accumbens core and shell would have different effects on impulsivity. Rats received bilateral stimulation at the level of the nucleus accumbens core or shell during a reaction time task. Stimulation of the nucleus accumbens core significantly decreased impulsivity, while stimulation of the shell increased it. Our results support the hypothesis that the nucleus accumbens is a potential target to treat neuropsychiatric disorders related to impulsivity by deep brain stimulation. However, different behavioral effects resulting from stimulation of the subterritories should be taken into account. Crown
KW - Deep brain stimulation
KW - Nucleus accumbens
KW - Premature responding reaction time task
UR - http://www.scopus.com/inward/record.url?scp=53949098953&partnerID=8YFLogxK
U2 - 10.1016/j.expneurol.2008.07.015
DO - 10.1016/j.expneurol.2008.07.015
M3 - Article
C2 - 18762185
AN - SCOPUS:53949098953
SN - 0014-4886
VL - 214
SP - 135
EP - 139
JO - Experimental Neurology
JF - Experimental Neurology
IS - 1
ER -