TY - JOUR
T1 - Close communication between the subependymal serotonergic plexus and the neurogenic subventricular zone
AU - Jahanshahi, Ali
AU - Temel, Yasin
AU - Lim, Lee Wei
AU - Hoogland, Govert
AU - Steinbusch, Harry W.M.
PY - 2011/12
Y1 - 2011/12
N2 - Although many studies have appeared on the mechanisms of neurogenesis in the adult mammalian central nervous system, the challenge remains to identify the factors controlling this process. Among numerous factors, which have been described to influence neurogenesis, serotonin (5-hydroxytryptamine, 5-HT) has received considerable attention. 5-HT drug manipulations and their effects on neurogenesis have revealed that 5-HT contributes to adult neurogenesis. An interesting but relatively unexplored detail is the presence of an extensive plexus of 5-HT containing fibers in the subventricular zone, the main neurogenic brain structure besides the dentate gyrus in the hippocampal formation. A dense plexus of 5-HT fibers surrounds the subventricular zone, separating this region from the adjacent structures of the lateral ventricle. This close anatomical relationship suggests an important functional role for 5-HT in influencing cell proliferation in the subventricular zone. Here, we review the literature and propose that subependymal plexus is part of an intrinsic brain mechanism which controls the subventricular zone cell proliferative capacity by modulating 5-HT release.
AB - Although many studies have appeared on the mechanisms of neurogenesis in the adult mammalian central nervous system, the challenge remains to identify the factors controlling this process. Among numerous factors, which have been described to influence neurogenesis, serotonin (5-hydroxytryptamine, 5-HT) has received considerable attention. 5-HT drug manipulations and their effects on neurogenesis have revealed that 5-HT contributes to adult neurogenesis. An interesting but relatively unexplored detail is the presence of an extensive plexus of 5-HT containing fibers in the subventricular zone, the main neurogenic brain structure besides the dentate gyrus in the hippocampal formation. A dense plexus of 5-HT fibers surrounds the subventricular zone, separating this region from the adjacent structures of the lateral ventricle. This close anatomical relationship suggests an important functional role for 5-HT in influencing cell proliferation in the subventricular zone. Here, we review the literature and propose that subependymal plexus is part of an intrinsic brain mechanism which controls the subventricular zone cell proliferative capacity by modulating 5-HT release.
KW - Neurogenesis
KW - Serotonin
KW - Subependymal plexus
KW - Subventricular zone
UR - http://www.scopus.com/inward/record.url?scp=80555150630&partnerID=8YFLogxK
U2 - 10.1016/j.jchemneu.2011.09.001
DO - 10.1016/j.jchemneu.2011.09.001
M3 - Review article
C2 - 21924347
AN - SCOPUS:80555150630
SN - 0891-0618
VL - 42
SP - 297
EP - 303
JO - Journal of Chemical Neuroanatomy
JF - Journal of Chemical Neuroanatomy
IS - 4
ER -