Projects per year
Personal profile
Personal profile
Prof. Wang was the founding Executive Dean of Academy of Pharmacy. He earned his PhD in Bio-Organic Chemistry from Washington University in St. Louis, Missouri, USA, and was an NIH/NRSA postdoctoral fellow studying mechanisms of DNA repair in mammalian system. Before joining XJTLU, he was a tenured faculty member in the Department of Biochemistry and Molecular Biology at Indiana University School of Medicine (IUSM), USA. He joined the faculty of Indiana University School of Medicine in 2001 as the Scientific Director of a newly established Proteomics Core. In 2004, he spearheaded a biotech CRO, Monarch Life Sciences, and served as Executive VP of Research until 2010. He also served as the director of Protein Analysis Research Center at IUSM from 2001 to 2016. His research centers around biomarkers and drug target discovery, and deciphering the protein interaction networks in complex human diseases such as cancer with the use of high throughput proteomics technologies such as quantitative mass spectrometry platforms. Additionally, he also has expertise in mammalian DNA repair and macro-molecular interaction studies using surface plasmon resonance (SPR) analysis. He has collaborated with more than 100 basic and clinical investigators both across the United States and internationally to advance knowledge related to human health. He has supervised more than 60 graduate students, postdoctoral fellows, and research associates. He was also a Co-Principal Investigator on the U.S. National Cancer Institute’s Clinical Proteomics Technologies Application for Cancer (CPTAC) Program. He received a number of awards including a Young Investigator’s Award in 2004 HUPO meeting. He has published more than 100 peer-reviewed articles in DNA repair, biochemistry, and proteomics related journals and book chapters, and served as an expert reviewer for many high-impact journals as well as NIH and the U.S. Department of Defense grant applications.
Research interests
Pathogenesis of Parkinsons Disease
Molecular Mechanisms of Drug Resistance in Cancer and Biomarker Development for Cisplatin Resistance in Human Ovarian Cancer
Targeting Alterred Pyruvate Metabolism for Prostate Cancer Therapy
Development of New Strategies/Methodologies in Proteomics/Metabolomics and Their Applications in Biomedical Research
Biomarker Clinical Applications
Experience
Executive Dean Professor, Academy of Pharmacy, Xian Jiaotong-Liverpool University, Suzhou, China, 2020-2023
Head of Department, Department of Biological Sciences, Xian Jiaotong-Liverpool University, Suzhou, China, 2018-2022
Tenured Associate Professor, Biochemistry Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA – 2010-2018
Tenure-track Assistant Professor, Biochemistry Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA – 2004-2010
Assistant Scientist, Assistant Professor (part-time), Biochemistry Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA – 2001-2004
Director of Proteomics, Indiana University School of Medicine, Indianapolis, Indiana, USA – 2001-2016
Vice President of Research Development, Monarch Life Sciences, Indianapolis, Indiana, USA – 2004-2010
NIH/NSRA Postdoctoral Fellow, Indiana University School of Medicine, Indianapolis, Indiana, USA – 1998-2001
Teaching
BIO312 Protein Structure and Function
BIO108 Organic Chemistry for Biologists
BIO401 Research Methods in Biotechnology
APH001
APH404
BIO312
BIO401
Awards and honours
Guest on “Sound Medicine” radio interview, USA, 2007
Guest on the journal “Proteomics” webcast – Cisplatin resistance of ovarian cancer, 2006
Interview Guest on World Talk Radio (San Francisco) – Science Society, USA
Young Investigator Award, International Human Proteome Organization, 2004
Invited Guest Speaker, American Broadcasting Company (ABC)’s Webcast on Proteomics as a new tool for biomedical sciences, USA
Individual National Research Service Award (F32), National Institutes of Health (NIH), USA
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Ph.D., Bio-organic Chemistry, Washington University, St. Louis, Missouri, USA – 1998
M.S., Organic Chemistry, Oregon State University, Corvallis, Oregon, USA – 1993
B.S., Chemistry, Sichuan University, Chengdu, Sichuan, China – 1986
Person Types
- Staff
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Collaborations and top research areas from the last five years
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Role of GOT2 succinylation on mitochondrial metabolism in prostate cancer
1/01/23 → 31/12/25
Project: Internal Research Project
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The role of dimethylguanidino valeric acid (DMGV) in carbohydrate and lipid metabolism
1/09/22 → 31/08/25
Project: Internal Research Project
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XJTLU Wisdom Lake Macro-molecular Characterization Analysis Center
Wang, M., Lu, Z., Fu, L., Han, G., Kappes, F., Park, J., Meng, J., Wang, R., Yue, C., Liu, X., Sacitharan, P., Jiang, J., Wu, J., Feng, Q., Sun, J., Chen, Y., Li, T., Jiang, B., Li, W., Qi, M., Yi, Y., O', D., Li, M., Zhao, C. & Carrillo, D.
1/11/20 → 31/10/23
Project: Governmental Research Project
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Global acetylome profiling indicates EPA impedes but OA promotes prostate cancer motility through altered acetylation of PFN1 and FLNA
He, C., Chen, X., Chen, Y., Sun, J., Qi, M., Rocha, S. & Wang, M., 2024, (Accepted/In press) In: Proteomics.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Translocational attenuation mediated by the PERK-SRP14 axis is a protective mechanism of unfolded protein response
Liu, Y., Gu, Y., Chen, Y., Wang, X., Zhou, G., Li, J., Wang, M., Fang, S. & Yang, Y., 23 Jul 2024, In: Cell Reports. 43, 7, 114402.Research output: Contribution to journal › Article › peer-review
Open Access -
系统生物学中的蛋白质组学方法与实验指南
Wang, Y., 张庆华 (ed.) & Wang, M. (ed.), 2024, 科学出版社. 234 p.Translated title of the contribution :Proteomics in Systems Biology Methods and Protocols Research output: Book/Report/Edited volume › Book › peer-review
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Comprehensive analysis of the lysine succinylome in fish oil-treated prostate cancer cells
Jiang, Y., He, C., Ye, H., Xu, Q., Chen, X., Chen, Y., Sun, J., Rocha, S. & Wang, M., Nov 2023, In: Life Science Alliance. 6, 11, e202302131.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Proteomic analysis of murine kidney proximal tubule sub-segment derived cell lines reveals preferences in mitochondrial pathway activity
Ferreira, R. M., de Almeida, R., Culp, C., Witzmann, F., Wang, M., Kher, R., Nagami, G. T., Mohallem, R., Andolino, C. J., Aryal, U. K., Eadon, M. T. & Bacallao, R. L., 30 Oct 2023, In: Journal of Proteomics. 289, 104998.Research output: Contribution to journal › Article › peer-review