Quantum edge entropy for alzheimer’s disease analysis

Jianjia Wang*, Richard C. Wilson, Edwin R. Hancock

*Corresponding author for this work

Research output: Chapter in Book or Report/Conference proceedingConference Proceedingpeer-review

1 Citation (Scopus)

Abstract

In this paper, we explore how to the decompose the global statistical mechanical entropy of a network into components associated with its edges. Commencing from a statistical mechanical picture in which the normalised Laplacian matrix plays the role of Hamiltonian operator, thermodynamic entropy can be calculated from partition function associated with different energy level occupation distributions arising from Bose-Einstein statistics and Fermi-Dirac statistics. Using the spectral decomposition of the Laplacian, we show how to project the edge-entropy components so that the detailed distribution of entropy across the edges of a network can be achieved. We apply the resulting method to fMRI activation networks to evaluate the qualitative and quantitative characterisations. The entropic measurement turns out to be an effective tool to identify the differences in structure of Alzheimer’s disease by selecting the most salient anatomical brain regions.

Original languageEnglish
Title of host publicationStructural, Syntactic, and Statistical Pattern Recognition - Joint IAPR International Workshop, S+SSPR 2018, Proceedings
EditorsEdwin R. Hancock, Tin Kam Ho, Battista Biggio, Richard C. Wilson, Antonio Robles-Kelly, Xiao Bai
PublisherSpringer Verlag
Pages449-459
Number of pages11
ISBN (Print)9783319977843
DOIs
Publication statusPublished - 2018
Externally publishedYes
EventJoint IAPR International Workshops on Structural and Syntactic Pattern Recognition, SSPR 2018 and Statistical Techniques in Pattern Recognition, SPR 2018 - Beijing, China
Duration: 17 Aug 201819 Aug 2018

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11004 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

ConferenceJoint IAPR International Workshops on Structural and Syntactic Pattern Recognition, SSPR 2018 and Statistical Techniques in Pattern Recognition, SPR 2018
Country/TerritoryChina
CityBeijing
Period17/08/1819/08/18

Keywords

  • Alzheimer’s disease
  • Bose-Einstein statistics
  • Fermi-Dirac statistics
  • Network entropy

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