TY - JOUR
T1 - Multi-layer SPR biosensor for in-Situ Amplified monitoring of the SARS-CoV-2 omicron (B.1.1.529) variant
AU - Akib, Tarik Bin Abdul
AU - Rana, Md Masud
AU - Mehedi, Ibrahim M.
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2024/2
Y1 - 2024/2
N2 - This article represents an analysis of the performance of multi-layer surface plasmon resonance (SPR) biosensors in detecting the transferable human SARS-CoV-2 Omicron (B.1.1.529) variant. The proposed multi-layer SPR biosensor performance is enhanced by integrating fine-tuning prisms, plasmonic metals, and two-dimensional (2D) transition metal dichalcogenides (TMDs) materials. To evaluate the performance of the multi-layer SPR sensor, the transfer matrix method (TMM) is employed. In numerical result, the proposed (CaF2/Cu/BP/Graphene) structure demonstrates the most favorable sensitivity and detection accuracy, characterized by a 410° angle shift sensitivity/refractive index unit (RIU). Additionally, the sensor achieves a detection accuracy (DA) of 0.4713, a quality factor (QF) of 94.25 RIU−1, a figure of merit (FOM) of 91.87, and a combined sensitivity factor (CSF) of 90.36. The presented sensor is also capable of detecting target biomolecule binding interactions between ligands and analytes at a range of concentrations (from 0 nM to 1000 nM), implying its potential use for detecting the omicron virus strain. The outcomes highlight the effectiveness of the presented sensor for real time, and label free detection, particularly in identifying the Omicron viral strain. Eventually, this research promises advanced biosensor technology, crucial for rapid viral variant detection and diagnostics.
AB - This article represents an analysis of the performance of multi-layer surface plasmon resonance (SPR) biosensors in detecting the transferable human SARS-CoV-2 Omicron (B.1.1.529) variant. The proposed multi-layer SPR biosensor performance is enhanced by integrating fine-tuning prisms, plasmonic metals, and two-dimensional (2D) transition metal dichalcogenides (TMDs) materials. To evaluate the performance of the multi-layer SPR sensor, the transfer matrix method (TMM) is employed. In numerical result, the proposed (CaF2/Cu/BP/Graphene) structure demonstrates the most favorable sensitivity and detection accuracy, characterized by a 410° angle shift sensitivity/refractive index unit (RIU). Additionally, the sensor achieves a detection accuracy (DA) of 0.4713, a quality factor (QF) of 94.25 RIU−1, a figure of merit (FOM) of 91.87, and a combined sensitivity factor (CSF) of 90.36. The presented sensor is also capable of detecting target biomolecule binding interactions between ligands and analytes at a range of concentrations (from 0 nM to 1000 nM), implying its potential use for detecting the omicron virus strain. The outcomes highlight the effectiveness of the presented sensor for real time, and label free detection, particularly in identifying the Omicron viral strain. Eventually, this research promises advanced biosensor technology, crucial for rapid viral variant detection and diagnostics.
KW - Biosensor
KW - COVID-19
KW - Omicron (B.1.1.529)
KW - SARS-CoV-2
KW - SPR
UR - http://www.scopus.com/inward/record.url?scp=85182589256&partnerID=8YFLogxK
U2 - 10.1016/j.biosx.2023.100434
DO - 10.1016/j.biosx.2023.100434
M3 - Article
AN - SCOPUS:85182589256
SN - 2590-1370
VL - 16
JO - Biosensors and Bioelectronics: X
JF - Biosensors and Bioelectronics: X
M1 - 100434
ER -