TY - JOUR
T1 - M7GHub
T2 - Deciphering the location, regulation and pathogenesis of internal mRNA N7-methylguanosine (m7G) sites in human
AU - Song, Bowen
AU - Tang, Yujiao
AU - Chen, Kunqi
AU - Wei, Zhen
AU - Rong, Rong
AU - Lu, Zhiliang
AU - Su, Jionglong
AU - De Magalhães, João Pedro
AU - Rigden, Daniel J.
AU - Jia, Meng
N1 - Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press. All rights reserved.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Motivation: Recent progress in N7-methylguanosine (m7G) RNA methylation studies has focused on its internal (rather than capped) presence within mRNAs. Tens of thousands of internal mRNA m7G sites have been identified within mammalian transcriptomes, and a single resource to best share, annotate and analyze the massive m7G data generated recently are sorely needed. Results: We report here m7GHub, a comprehensive online platform for deciphering the location, regulation and pathogenesis of internal mRNA m7G. The m7GHub consists of four main components, including: the first internal mRNA m7G database containing 44 058 experimentally validated internal mRNA m7G sites, a sequence-based highaccuracy predictor, the first web server for assessing the impact of mutations on m7G status, and the first database recording 1218 disease-associated genetic mutations that may function through regulation of m7G methylation. Together, m7GHub will serve as a useful resource for research on internal mRNA m7G modification. Availability and implementation: m7GHub is freely accessible online at www.xjtlu.edu.cn/biologicalsciences/ m7ghub.
AB - Motivation: Recent progress in N7-methylguanosine (m7G) RNA methylation studies has focused on its internal (rather than capped) presence within mRNAs. Tens of thousands of internal mRNA m7G sites have been identified within mammalian transcriptomes, and a single resource to best share, annotate and analyze the massive m7G data generated recently are sorely needed. Results: We report here m7GHub, a comprehensive online platform for deciphering the location, regulation and pathogenesis of internal mRNA m7G. The m7GHub consists of four main components, including: the first internal mRNA m7G database containing 44 058 experimentally validated internal mRNA m7G sites, a sequence-based highaccuracy predictor, the first web server for assessing the impact of mutations on m7G status, and the first database recording 1218 disease-associated genetic mutations that may function through regulation of m7G methylation. Together, m7GHub will serve as a useful resource for research on internal mRNA m7G modification. Availability and implementation: m7GHub is freely accessible online at www.xjtlu.edu.cn/biologicalsciences/ m7ghub.
UR - http://www.scopus.com/inward/record.url?scp=85085962514&partnerID=8YFLogxK
U2 - 10.1093/bioinformatics/btaa178
DO - 10.1093/bioinformatics/btaa178
M3 - Article
C2 - 32163126
AN - SCOPUS:85085962514
SN - 1367-4803
VL - 36
SP - 3528
EP - 3536
JO - Bioinformatics
JF - Bioinformatics
IS - 11
ER -