Homeostatic DNMT3a activity is required to restore cognition and hippocampal DNA methylation in the 5xFAD model of Alzheimer’s disease

Yanzhi Liu; Chi Him Poon; Long Sum Rachel  Tse; Jaydeep Roy; Charlotte Theodora So; Benjamin Chun-Kit  Tong; Kwok-Ming Yao; George Lim Tipoe; Harry W.M. Steinbusch; Luca Aquili; Alan Kaluev; King-Ho Cheung; Man-Lung Fung; Lee Wei Lim

doi:10.14336/AD.2025.0283

Homeostatic DNMT3a activity is required to restore cognition and hippocampal DNA methylation in the 5xFAD model of Alzheimer’s disease

Yanzhi Liu, Chi Him Poon, Long Sum Rachel Tse, Jaydeep Roy, Charlotte Theodora So, Benjamin Chun-Kit Tong, Kwok-Ming Yao, George Lim Tipoe, Harry W.M. Steinbusch, Luca Aquili, Alan Kaluev, King-Ho Cheung, Man-Lung Fung, Lee Wei Lim^*

^*Corresponding author for this work

Department of Biosciences and Bioinformatics

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Aging and Disease
Volume	17
Issue number	4
DOIs	https://doi.org/10.14336/AD.2025.0283
Publication status	Published - 2025

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10.14336/AD.2025.0283Licence: CC BY-ND

Cite this

Liu, Y., Poon, C. H., Tse, L. S. R., Roy, J., So, C. T., Tong, B. C.-K., Yao, K.-M., Tipoe, G. L., Steinbusch, H. W. M., Aquili, L., Kaluev, A., Cheung, K.-H., Fung, M.-L., & Lim, L. W. (2025). Homeostatic DNMT3a activity is required to restore cognition and hippocampal DNA methylation in the 5xFAD model of Alzheimer’s disease. Aging and Disease, 17(4). https://doi.org/10.14336/AD.2025.0283

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title = "Homeostatic DNMT3a activity is required to restore cognition and hippocampal DNA methylation in the 5xFAD model of Alzheimer{\textquoteright}s disease",

author = "Yanzhi Liu and Poon, {Chi Him} and Tse, {Long Sum Rachel} and Jaydeep Roy and So, {Charlotte Theodora} and Tong, {Benjamin Chun-Kit} and Kwok-Ming Yao and Tipoe, {George Lim} and Steinbusch, {Harry W.M.} and Luca Aquili and Alan Kaluev and King-Ho Cheung and Man-Lung Fung and Lim, {Lee Wei}",

year = "2025",

doi = "10.14336/AD.2025.0283",

language = "English",

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TY - JOUR

T1 - Homeostatic DNMT3a activity is required to restore cognition and hippocampal DNA methylation in the 5xFAD model of Alzheimer’s disease

AU - Liu, Yanzhi

AU - Poon, Chi Him

AU - Tse, Long Sum Rachel

AU - Roy, Jaydeep

AU - So, Charlotte Theodora

AU - Tong, Benjamin Chun-Kit

AU - Yao, Kwok-Ming

AU - Tipoe, George Lim

AU - Steinbusch, Harry W.M.

AU - Aquili, Luca

AU - Kaluev, Alan

AU - Cheung, King-Ho

AU - Fung, Man-Lung

AU - Lim, Lee Wei

PY - 2025

Y1 - 2025

U2 - 10.14336/AD.2025.0283

DO - 10.14336/AD.2025.0283

M3 - Article

SN - 2152-5250

VL - 17

JO - Aging and Disease

JF - Aging and Disease

IS - 4

ER -