Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs

Maria O. Nerush; Vadim A. Shevyrin; Nikita I. Golushko; Anastasia M. Moskalenko; Denis B. Rosemberg; Murilo S. De Abreu; Long En Yang; David S. Galstyan; Lee Wei Lim; Konstantin A. Demin; Allan V. Kalueff

doi:10.1021/acschemneuro.4c00505

Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs

Maria O. Nerush, Vadim A. Shevyrin, Nikita I. Golushko, Anastasia M. Moskalenko, Denis B. Rosemberg, Murilo S. De Abreu, Long En Yang, David S. Galstyan, Lee Wei Lim, Konstantin A. Demin^*, Allan V. Kalueff^*

^*Corresponding author for this work

Xi'an Jiaotong-Liverpool University

Research output: Contribution to journal › Review article › peer-review

Abstract

Antihistaminic drugs are widely used clinically and have long been primarily known for their use to treat severe allergic conditions caused by histamine release. Antihistaminic drugs also exert central nervous system (CNS) effects, acting as anxiolytics, hypnotics, and neuroleptics. However, these drugs also have multiple serious neuropharmacological side-effects, inducing delirium, hyperarousal, disorganized behavior, and hallucinations. Due to their robust CNS effects, antihistamines are also increasingly abused, with occasional overdoses and life-threatening toxicity. Here, we discuss chemical and neuropharmacological aspects of antihistaminic drugs in both human and animal (experimental) models and outline their current societal and mental health importance as neuroactive substances.

Original language	English
Pages (from-to)	3848-3862
Number of pages	15
Journal	ACS Chemical Neuroscience
Volume	15
Issue number	21
DOIs	https://doi.org/10.1021/acschemneuro.4c00505
Publication status	Published - 6 Nov 2024

Keywords

Animal models
Anticholinergic activity
Antihistamines
Delirium
Drug use and abuse
First generation H1 antagonists
Histamine
Side effects

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acschemneuro.4c00505

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title = "Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs",

abstract = "Antihistaminic drugs are widely used clinically and have long been primarily known for their use to treat severe allergic conditions caused by histamine release. Antihistaminic drugs also exert central nervous system (CNS) effects, acting as anxiolytics, hypnotics, and neuroleptics. However, these drugs also have multiple serious neuropharmacological side-effects, inducing delirium, hyperarousal, disorganized behavior, and hallucinations. Due to their robust CNS effects, antihistamines are also increasingly abused, with occasional overdoses and life-threatening toxicity. Here, we discuss chemical and neuropharmacological aspects of antihistaminic drugs in both human and animal (experimental) models and outline their current societal and mental health importance as neuroactive substances.",

keywords = "Animal models, Anticholinergic activity, Antihistamines, Delirium, Drug use and abuse, First generation H1 antagonists, Histamine, Side effects",

author = "Nerush, {Maria O.} and Shevyrin, {Vadim A.} and Golushko, {Nikita I.} and Moskalenko, {Anastasia M.} and Rosemberg, {Denis B.} and {De Abreu}, {Murilo S.} and Yang, {Long En} and Galstyan, {David S.} and Lim, {Lee Wei} and Demin, {Konstantin A.} and Kalueff, {Allan V.}",

note = "Publisher Copyright: {\textcopyright} 2024 American Chemical Society.",

year = "2024",

month = nov,

day = "6",

doi = "10.1021/acschemneuro.4c00505",

language = "English",

volume = "15",

pages = "3848--3862",

journal = "ACS Chemical Neuroscience",

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T2 - Deliriant Antihistaminic Drugs

AU - Nerush, Maria O.

AU - Shevyrin, Vadim A.

AU - Golushko, Nikita I.

AU - Moskalenko, Anastasia M.

AU - Rosemberg, Denis B.

AU - De Abreu, Murilo S.

AU - Yang, Long En

AU - Galstyan, David S.

AU - Lim, Lee Wei

AU - Demin, Konstantin A.

AU - Kalueff, Allan V.

PY - 2024/11/6

Y1 - 2024/11/6

N2 - Antihistaminic drugs are widely used clinically and have long been primarily known for their use to treat severe allergic conditions caused by histamine release. Antihistaminic drugs also exert central nervous system (CNS) effects, acting as anxiolytics, hypnotics, and neuroleptics. However, these drugs also have multiple serious neuropharmacological side-effects, inducing delirium, hyperarousal, disorganized behavior, and hallucinations. Due to their robust CNS effects, antihistamines are also increasingly abused, with occasional overdoses and life-threatening toxicity. Here, we discuss chemical and neuropharmacological aspects of antihistaminic drugs in both human and animal (experimental) models and outline their current societal and mental health importance as neuroactive substances.

AB - Antihistaminic drugs are widely used clinically and have long been primarily known for their use to treat severe allergic conditions caused by histamine release. Antihistaminic drugs also exert central nervous system (CNS) effects, acting as anxiolytics, hypnotics, and neuroleptics. However, these drugs also have multiple serious neuropharmacological side-effects, inducing delirium, hyperarousal, disorganized behavior, and hallucinations. Due to their robust CNS effects, antihistamines are also increasingly abused, with occasional overdoses and life-threatening toxicity. Here, we discuss chemical and neuropharmacological aspects of antihistaminic drugs in both human and animal (experimental) models and outline their current societal and mental health importance as neuroactive substances.

KW - Animal models

KW - Anticholinergic activity

KW - Antihistamines

KW - Delirium

KW - Drug use and abuse

KW - First generation H1 antagonists

KW - Histamine

KW - Side effects

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U2 - 10.1021/acschemneuro.4c00505

DO - 10.1021/acschemneuro.4c00505

M3 - Review article

C2 - 39404616

AN - SCOPUS:85206540443

SN - 1948-7193

VL - 15

SP - 3848

EP - 3862

JO - ACS Chemical Neuroscience

JF - ACS Chemical Neuroscience

IS - 21

ER -

Classics in Chemical Neuroscience: Deliriant Antihistaminic Drugs

Abstract

Keywords

UN SDGs

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