Projects per year
Personal profile
Personal profile
Dr. Shen received his PhD in Genetics Genomics and Master of Public Health in Public Health Policy and Management from the University of Florida (2018). Subsequently, he conducted postdoctoral research in Human Genetics at Harvard Medical School and the Broad Institute of MIT and Harvard. His research primarily focuses on utilizing genome editing techniques to investigate the regulatory mechanisms of hemoglobin gene expression in red blood cells and pioneering gene therapy approaches for severe genetic anemias, such as sickle cell disease and thalassemia. Dr. Shen has authored research papers and reviews in prominent journals spanning human genetics, molecular genetics, and molecular therapy, including Nature Communications, Molecular and Cellular Biology, PLOS Genetics, and Molecular Therapy - Nucleic Acid. In addition to his academic pursuits, Dr. Shen possesses extensive experience in innovation and entrepreneurship. He is dedicated to translating cutting-edge biomedical innovations into practical solutions for some of the most challenging human health issues, including genetic diseases, cancer, and aging.
Research interests
Epigenetic reprogramming interventions and gene therapy for aging reversal
Engineering of AAV gene therapy delivery vector
Establishment of epigenome editing system for gene expression modulation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Postdoc in Human Genetics, Harvard Medical School and Broad Institute of MIT and Harvard, 2018-2021
Ph.D. in Genetics and Genomics, University of Florida, 2018
M.P.H in Public Health Policy and Management, University of Florida, 2018
Person Types
- Staff
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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CRISPR Activation for Epigenetic Reprogramming to Reverse Cellular Aging
1/09/24 → 31/08/27
Project: Governmental Research Project
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CRISPR Activation for Epigenetic Reprogramming to Reverse Cellular Aging
1/07/24 → 30/06/27
Project: Internal Research Project
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Student performance and perceptions in the Global Classroom Initiative
Fendos, J., Raju, S., Shen, Y., Kam, A. & Yap, W. H.
17/04/24 → 31/12/26
Project: Collaborative Research Project
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CRISPR Activation for Epigenetic Reprogramming to Reverse Cellular Aging
Project: Governmental Research Project
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A unified model of human hemoglobin switching through single-cell genome editing
Shen, Y., Verboon, J. M., Zhang, Y., Liu, N., Kim, Y. J., Marglous, S., Nandakumar, S. K., Voit, R. A., Fiorini, C., Ejaz, A., Basak, A., Orkin, S. H., Xu, J. & Sankaran, V. G., 1 Dec 2021, In: Nature Communications. 12, 1, 4991.Research output: Contribution to journal › Article › peer-review
Open Access21 Citations (Scopus) -
Pathogenic BCL11A variants provide insights into the mechanisms of human fetal hemoglobin silencing
Shen, Y., Li, R., Teichert, K., Montbleau, K. E., Verboon, J. M., Voit, R. A. & Sankaran, V. G., 11 Oct 2021, In: PLoS Genetics. 17, 10, e1009835.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus) -
Erratum: Identification of a novel enhancer/ chromatin opening element associated with high-level γ-globin gene expression (Molecular and Cellular Biology (2018) 38:19 (e00197-18) DOI: 10.1128/MCB.00197-18)
Shen, Y., Bassett, M. A., Gurumurthy, A., Nar, R., Knudson, I. J., Guy, C. R., Perez, A., Mellen, R. W., Ikeda, M., Hossain, M. A., Huang, S., Igarashi, K. & Bungert, J., 2019, In: Molecular and Cellular Biology. 39, 11, e0016819.Research output: Contribution to journal › Comment/debate
Open Access2 Citations (Scopus) -
Phase Separation and Transcription Regulation: Are Super-Enhancers and Locus Control Regions Primary Sites of Transcription Complex Assembly?
Gurumurthy, A., Shen, Y., Gunn, E. M. & Bungert, J., Jan 2019, In: BioEssays. 41, 1, 1800164.Research output: Contribution to journal › Article › peer-review
Open Access29 Citations (Scopus) -
Computational design and experimental characterization of a novel β-common receptor inhibitory peptide
Kilar, C. R., Sekharan, S., Sautina, L., Diao, Y. P., Keinan, S., Shen, Y., Bungert, J., Mohandas, R. & Segal, M. S., Jun 2018, In: Peptides. 104, p. 1-6 6 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus)
Activities
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Organising Bio Department Seminar with Wu Min, Wenzhou Institute University of Chinese Academy of Sciences
Yong Shen (Organiser)
28 Jun 2024Activity: Participating in or organising an event › Organising an event e.g. a conference, workshop, …
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Take the Role of Program Director for Department of Biological Sciences
Yong Shen (Advisor)
3 Jun 2024 → 3 Jun 2025Activity: Consultancy
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Global Classroom Initiative with Taylor's University
Yong Shen (Participant)
29 May 2024Activity: Participating in or organising an event › Organising an event e.g. a conference, workshop, …
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Organising Bio Department Seminar with Stanley Lau, The Hong Kong University of Science and Technology
Yong Shen (Organiser)
17 Apr 2024Activity: Participating in or organising an event › Organising an event e.g. a conference, workshop, …
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Organising Bio Department Seminar with Prof. Alexey Semyanov, Director of Neuroscience Center, Medical School at Jiaxing University
Yong Shen (Participant)
1 Mar 2024Activity: Participating in or organising an event › Organising an event e.g. a conference, workshop, …