X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation

Lun Ma; Xiaoju Zou; Brian Bui; Wei Chen; Kwang Hyun Song; Timothy Solberg

doi:10.1063/1.4890105

X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation

Lun Ma, Xiaoju Zou, Brian Bui, Wei Chen^*, Kwang Hyun Song, Timothy Solberg

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

118 Citations (Scopus)

Abstract

Copper and cobalt co-doped ZnS (ZnS:Cu,Co) afterglow nanoparticles were conjugated to photosensitizer tetrabromorhodamine-123 (TBrRh123) and efficient energy transfer from the nanoparticles to TBrRh123 was observed. In addition to their X-ray excited luminescence, the ZnS:Cu,Co nanoparticles also show long lasting afterglow, which continuously serve as a light source for photodynamic therapy (PDT) activation. Compared to TBrRh123 or ZnS:Cu,Co alone, the ZnS:Cu,Co-TBrRh123 conjugates show low dark toxicity but high X-ray induced toxicity to human prostate cancer cells. The results indicate that the ZnS:Cu,Co afterglow nanoparticles have a good potential for PDT activation.

Original language	English
Article number	013702
Journal	Applied Physics Letters
Volume	105
Issue number	1
DOIs	https://doi.org/10.1063/1.4890105
Publication status	Published - 7 Jul 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1063/1.4890105

Cite this

Ma, L., Zou, X., Bui, B., Chen, W., Song, K. H., & Solberg, T. (2014). X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation. Applied Physics Letters, 105(1), Article 013702. https://doi.org/10.1063/1.4890105

@article{705c40b14ce44600ad4467793e008552,

title = "X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation",

abstract = "Copper and cobalt co-doped ZnS (ZnS:Cu,Co) afterglow nanoparticles were conjugated to photosensitizer tetrabromorhodamine-123 (TBrRh123) and efficient energy transfer from the nanoparticles to TBrRh123 was observed. In addition to their X-ray excited luminescence, the ZnS:Cu,Co nanoparticles also show long lasting afterglow, which continuously serve as a light source for photodynamic therapy (PDT) activation. Compared to TBrRh123 or ZnS:Cu,Co alone, the ZnS:Cu,Co-TBrRh123 conjugates show low dark toxicity but high X-ray induced toxicity to human prostate cancer cells. The results indicate that the ZnS:Cu,Co afterglow nanoparticles have a good potential for PDT activation.",

author = "Lun Ma and Xiaoju Zou and Brian Bui and Wei Chen and Song, {Kwang Hyun} and Timothy Solberg",

note = "Publisher Copyright: {\textcopyright} 2014 AIP Publishing LLC.",

year = "2014",

month = jul,

day = "7",

doi = "10.1063/1.4890105",

language = "English",

volume = "105",

journal = "Applied Physics Letters",

issn = "0003-6951",

number = "1",

}

TY - JOUR

T1 - X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation

AU - Ma, Lun

AU - Zou, Xiaoju

AU - Bui, Brian

AU - Chen, Wei

AU - Song, Kwang Hyun

AU - Solberg, Timothy

PY - 2014/7/7

Y1 - 2014/7/7

N2 - Copper and cobalt co-doped ZnS (ZnS:Cu,Co) afterglow nanoparticles were conjugated to photosensitizer tetrabromorhodamine-123 (TBrRh123) and efficient energy transfer from the nanoparticles to TBrRh123 was observed. In addition to their X-ray excited luminescence, the ZnS:Cu,Co nanoparticles also show long lasting afterglow, which continuously serve as a light source for photodynamic therapy (PDT) activation. Compared to TBrRh123 or ZnS:Cu,Co alone, the ZnS:Cu,Co-TBrRh123 conjugates show low dark toxicity but high X-ray induced toxicity to human prostate cancer cells. The results indicate that the ZnS:Cu,Co afterglow nanoparticles have a good potential for PDT activation.

AB - Copper and cobalt co-doped ZnS (ZnS:Cu,Co) afterglow nanoparticles were conjugated to photosensitizer tetrabromorhodamine-123 (TBrRh123) and efficient energy transfer from the nanoparticles to TBrRh123 was observed. In addition to their X-ray excited luminescence, the ZnS:Cu,Co nanoparticles also show long lasting afterglow, which continuously serve as a light source for photodynamic therapy (PDT) activation. Compared to TBrRh123 or ZnS:Cu,Co alone, the ZnS:Cu,Co-TBrRh123 conjugates show low dark toxicity but high X-ray induced toxicity to human prostate cancer cells. The results indicate that the ZnS:Cu,Co afterglow nanoparticles have a good potential for PDT activation.

UR - http://www.scopus.com/inward/record.url?scp=84908546288&partnerID=8YFLogxK

U2 - 10.1063/1.4890105

DO - 10.1063/1.4890105

M3 - Article

AN - SCOPUS:84908546288

SN - 0003-6951

VL - 105

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 1

M1 - 013702

ER -

X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this