X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation

Lun Ma, Xiaoju Zou, Brian Bui, Wei Chen*, Kwang Hyun Song, Timothy Solberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

116 Citations (Scopus)

Abstract

Copper and cobalt co-doped ZnS (ZnS:Cu,Co) afterglow nanoparticles were conjugated to photosensitizer tetrabromorhodamine-123 (TBrRh123) and efficient energy transfer from the nanoparticles to TBrRh123 was observed. In addition to their X-ray excited luminescence, the ZnS:Cu,Co nanoparticles also show long lasting afterglow, which continuously serve as a light source for photodynamic therapy (PDT) activation. Compared to TBrRh123 or ZnS:Cu,Co alone, the ZnS:Cu,Co-TBrRh123 conjugates show low dark toxicity but high X-ray induced toxicity to human prostate cancer cells. The results indicate that the ZnS:Cu,Co afterglow nanoparticles have a good potential for PDT activation.

Original languageEnglish
Article number013702
JournalApplied Physics Letters
Volume105
Issue number1
DOIs
Publication statusPublished - 7 Jul 2014
Externally publishedYes

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