TY - JOUR
T1 - X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation
AU - Ma, Lun
AU - Zou, Xiaoju
AU - Bui, Brian
AU - Chen, Wei
AU - Song, Kwang Hyun
AU - Solberg, Timothy
N1 - Publisher Copyright:
© 2014 AIP Publishing LLC.
PY - 2014/7/7
Y1 - 2014/7/7
N2 - Copper and cobalt co-doped ZnS (ZnS:Cu,Co) afterglow nanoparticles were conjugated to photosensitizer tetrabromorhodamine-123 (TBrRh123) and efficient energy transfer from the nanoparticles to TBrRh123 was observed. In addition to their X-ray excited luminescence, the ZnS:Cu,Co nanoparticles also show long lasting afterglow, which continuously serve as a light source for photodynamic therapy (PDT) activation. Compared to TBrRh123 or ZnS:Cu,Co alone, the ZnS:Cu,Co-TBrRh123 conjugates show low dark toxicity but high X-ray induced toxicity to human prostate cancer cells. The results indicate that the ZnS:Cu,Co afterglow nanoparticles have a good potential for PDT activation.
AB - Copper and cobalt co-doped ZnS (ZnS:Cu,Co) afterglow nanoparticles were conjugated to photosensitizer tetrabromorhodamine-123 (TBrRh123) and efficient energy transfer from the nanoparticles to TBrRh123 was observed. In addition to their X-ray excited luminescence, the ZnS:Cu,Co nanoparticles also show long lasting afterglow, which continuously serve as a light source for photodynamic therapy (PDT) activation. Compared to TBrRh123 or ZnS:Cu,Co alone, the ZnS:Cu,Co-TBrRh123 conjugates show low dark toxicity but high X-ray induced toxicity to human prostate cancer cells. The results indicate that the ZnS:Cu,Co afterglow nanoparticles have a good potential for PDT activation.
UR - http://www.scopus.com/inward/record.url?scp=84908546288&partnerID=8YFLogxK
U2 - 10.1063/1.4890105
DO - 10.1063/1.4890105
M3 - Article
AN - SCOPUS:84908546288
SN - 0003-6951
VL - 105
JO - Applied Physics Letters
JF - Applied Physics Letters
IS - 1
M1 - 013702
ER -
