Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy

Wenjun Zhu, Yu Yang, Qiutong Jin, Yu Chao, Longlong Tian, Jingjing Liu, Ziliang Dong, Zhuang Liu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)

Abstract

Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms. In addition to conventional particulate NMOFs, two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications. Herein, 2D-NMOFs composed of Zn2+ and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG). Compared to their particulate counterpart, such 2D-NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production, promising for chemotherapy and photodynamic therapy (PDT), respectively. Utilizing the porphyrin structure of TCPP, our 2D-NMOFs could be labeled with a diagnostic radioisotope, 99mTc, for single photon emission computer tomography (SPECT) imaging, which reveals efficient tumor homing of those 2D-NMOFs upon intravenous injection. While offering a remarkable synergistic in vivo antitumor effect for the combined chemo-PDT, such 2D-NMOFs show efficient biodegradation and rapid renal clearance. Our work presents the great promise of 2D-NMOFs for nanomedicine applications. [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)1307-1312
Number of pages6
JournalNano Research
Volume12
Issue number6
DOIs
Publication statusPublished - 1 Jun 2019
Externally publishedYes

Keywords

  • combination therapy
  • drug delivery
  • nanoscale metal-organic-framework
  • photodynamic therapy
  • two-dimensional nanosheets

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