TY - JOUR
T1 - Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders
AU - Kabir, Md Tanvir
AU - Rahman, Md Habibur
AU - Shah, Muddaser
AU - Jamiruddin, Mohd Raeed
AU - Basak, Debasish
AU - Al-Harrasi, Ahmed
AU - Bhatia, Saurabh
AU - Ashraf, Ghulam Md
AU - Najda, Agnieszka
AU - El-kott, Attalla F.
AU - Mohamed, Hanan R.H.
AU - Al-malky, Hamdan S.
AU - Germoush, Mousa O.
AU - Altyar, Ahmed E.
AU - Alwafai, Esraa B.
AU - Ghaboura, Nehmat
AU - Abdel-Daim, Mohamed M.
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/2
Y1 - 2022/2
N2 - Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have various disease-specific causal factors and pathological features. A very common characteristic of NDs is oxidative stress (OS), which takes place due to the elevated generation of reactive oxygen species during the progression of NDs. Furthermore, the pathological condition of NDs including an increased level of protein aggregates can further lead to chronic inflammation because of the microglial activation. Carotenoids (CTs) are naturally occurring pigments that play a significant role in averting brain disorders. More than 750 CTs are present in nature, and they are widely available in plants, microorganisms, and animals. CTs are accountable for the red, yellow, and orange pigments in several animals and plants, and these colors usually indicate various types of CTs. CTs exert various bioactive properties because of its characteristic structure, including anti-inflammatory and antioxidant properties. Due to the protective properties of CTs, levels of CTs in the human body have been markedly linked with the prevention and treatment of multiple diseases including NDs. In this review, we have summarized the relationship between OS, neuroinflammation, and NDs. In addition, we have also particularly focused on the antioxidants and anti-inflammatory properties of CTs in the management of NDs.
AB - Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have various disease-specific causal factors and pathological features. A very common characteristic of NDs is oxidative stress (OS), which takes place due to the elevated generation of reactive oxygen species during the progression of NDs. Furthermore, the pathological condition of NDs including an increased level of protein aggregates can further lead to chronic inflammation because of the microglial activation. Carotenoids (CTs) are naturally occurring pigments that play a significant role in averting brain disorders. More than 750 CTs are present in nature, and they are widely available in plants, microorganisms, and animals. CTs are accountable for the red, yellow, and orange pigments in several animals and plants, and these colors usually indicate various types of CTs. CTs exert various bioactive properties because of its characteristic structure, including anti-inflammatory and antioxidant properties. Due to the protective properties of CTs, levels of CTs in the human body have been markedly linked with the prevention and treatment of multiple diseases including NDs. In this review, we have summarized the relationship between OS, neuroinflammation, and NDs. In addition, we have also particularly focused on the antioxidants and anti-inflammatory properties of CTs in the management of NDs.
KW - Anti-inflammatory
KW - Antioxidant
KW - Inflammation
KW - Microglia
KW - Neurodegenerative disorders
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85122153584&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2021.112610
DO - 10.1016/j.biopha.2021.112610
M3 - Review article
C2 - 35062074
AN - SCOPUS:85122153584
SN - 0753-3322
VL - 146
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
M1 - 112610
ER -
