TY - JOUR
T1 - The vitamin D neuroendocrine system as a target for novel neurotropic drugs
AU - Kalueff, A. V.
AU - Minasyan, A.
AU - Keisala, T.
AU - Kuuslahti, M.
AU - Miettinen, S.
AU - Tuohimaa, P.
PY - 2006/6
Y1 - 2006/6
N2 - Vitamin D is a seco-steroid hormone with multiple functions in the nervous system. Physiological brain mechanisms of vitamin D and its receptors include neuroprotection, antiepileptic effects, immunomodulation, possible interplay with several brain neurotransmitter systems and hormones, as well as the regulation of behaviours. Here we review the important role of the vitamin D neuroendocrine system in the brain, and outline perspectives for the search for novel neurotropic drugs to treat various vitamin D-related dysfunctions.
AB - Vitamin D is a seco-steroid hormone with multiple functions in the nervous system. Physiological brain mechanisms of vitamin D and its receptors include neuroprotection, antiepileptic effects, immunomodulation, possible interplay with several brain neurotransmitter systems and hormones, as well as the regulation of behaviours. Here we review the important role of the vitamin D neuroendocrine system in the brain, and outline perspectives for the search for novel neurotropic drugs to treat various vitamin D-related dysfunctions.
KW - Brain disorders
KW - Neurosteroid hormone
KW - New drugs
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=33745115907&partnerID=8YFLogxK
U2 - 10.2174/187152706784111506
DO - 10.2174/187152706784111506
M3 - Review article
C2 - 16787236
AN - SCOPUS:33745115907
SN - 1871-5273
VL - 5
SP - 363
EP - 371
JO - CNS and Neurological Disorders - Drug Targets
JF - CNS and Neurological Disorders - Drug Targets
IS - 3
ER -