TY - JOUR
T1 - The role of vitamins in neurodegenerative disease
T2 - An update
AU - Rai, Sachchida Nand
AU - Singh, Payal
AU - Steinbusch, Harry W.M.
AU - Vamanu, Emanuel
AU - Ashraf, Ghulam
AU - Singh, Mohan Prasad
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/10
Y1 - 2021/10
N2 - Acquiring the recommended daily allowance of vitamins is crucial for maintaining homeo-static balance in humans and other animals. A deficiency in or dysregulation of vitamins adversely affects the neuronal metabolism, which may lead to neurodegenerative diseases. In this article, we discuss how novel vitamin-based approaches aid in attenuating abnormal neuronal functioning in neurodegeneration-based brain diseases such as Alzheimer’s disease, Parkinson’s disease, Hunt-ington’s disease, Amyotrophic lateral sclerosis, and Prion disease. Vitamins show their therapeutic activity in Parkinson’s disease by antioxidative and anti-inflammatory activity. In addition, different water-and lipid-soluble vitamins have also prevented amyloid beta and tau pathology. On the other hand, some results also show no correlation between vitamin action and the prevention of neurodegenerative diseases. Some vitamins also exhibit toxic activity too. This review discusses both the beneficial and null effects of vitamin supplementation for neurological disorders. The de-tailed mechanism of action of both water-and lipid-soluble vitamins is addressed in the manuscript. Hormesis is also an essential factor that is very helpful to determine the effective dose of vitamins. PubMed, Google Scholar, Web of Science, and Scopus were employed to conduct the literature search of original articles, review articles, and meta-analyses.
AB - Acquiring the recommended daily allowance of vitamins is crucial for maintaining homeo-static balance in humans and other animals. A deficiency in or dysregulation of vitamins adversely affects the neuronal metabolism, which may lead to neurodegenerative diseases. In this article, we discuss how novel vitamin-based approaches aid in attenuating abnormal neuronal functioning in neurodegeneration-based brain diseases such as Alzheimer’s disease, Parkinson’s disease, Hunt-ington’s disease, Amyotrophic lateral sclerosis, and Prion disease. Vitamins show their therapeutic activity in Parkinson’s disease by antioxidative and anti-inflammatory activity. In addition, different water-and lipid-soluble vitamins have also prevented amyloid beta and tau pathology. On the other hand, some results also show no correlation between vitamin action and the prevention of neurodegenerative diseases. Some vitamins also exhibit toxic activity too. This review discusses both the beneficial and null effects of vitamin supplementation for neurological disorders. The de-tailed mechanism of action of both water-and lipid-soluble vitamins is addressed in the manuscript. Hormesis is also an essential factor that is very helpful to determine the effective dose of vitamins. PubMed, Google Scholar, Web of Science, and Scopus were employed to conduct the literature search of original articles, review articles, and meta-analyses.
KW - Alzheimer’s disease
KW - Huntington disease
KW - Neurodegenerative disease
KW - Parkinson’s disease
KW - Prion disease
KW - Vitamins
UR - http://www.scopus.com/inward/record.url?scp=85115753861&partnerID=8YFLogxK
U2 - 10.3390/biomedicines9101284
DO - 10.3390/biomedicines9101284
M3 - Review article
AN - SCOPUS:85115753861
SN - 2227-9059
VL - 9
JO - Biomedicines
JF - Biomedicines
IS - 10
M1 - 1284
ER -