The origins of SARS-CoV-2: A critical review

Edward C. Holmes; Stephen A. Goldstein; Angela L. Rasmussen; David L. Robertson; Alexander Crits-Christoph; Joel O. Wertheim; Simon J. Anthony; Wendy S. Barclay; Maciej F. Boni; Peter C. Doherty; Jeremy Farrar; Jemma L. Geoghegan; Xiaowei Jiang; Julian L. Leibowitz; Stuart J.D. Neil; Tim Skern; Susan R. Weiss; Michael Worobey; Kristian G. Andersen; Robert F. Garry; Andrew Rambaut

doi:10.1016/j.cell.2021.08.017

The origins of SARS-CoV-2: A critical review

Edward C. Holmes^*, Stephen A. Goldstein, Angela L. Rasmussen, David L. Robertson, Alexander Crits-Christoph, Joel O. Wertheim, Simon J. Anthony, Wendy S. Barclay, Maciej F. Boni, Peter C. Doherty, Jeremy Farrar, Jemma L. Geoghegan, Xiaowei Jiang, Julian L. Leibowitz, Stuart J.D. Neil, Tim Skern, Susan R. Weiss, Michael Worobey, Kristian G. Andersen, Robert F. GarryAndrew Rambaut^*

^*Corresponding author for this work

Department of Biological Sciences

Research output: Contribution to journal › Review article › peer-review

316 Citations (Scopus)

Abstract

Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a “laboratory escape” scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.

Original language	English
Pages (from-to)	4848-4856
Number of pages	9
Journal	Cell
Volume	184
Issue number	19
DOIs	https://doi.org/10.1016/j.cell.2021.08.017
Publication status	Published - 16 Sept 2021

Keywords

COVID-19
SARS-CoV-2
evolution
origins
zoonosis

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Holmes, E. C., Goldstein, S. A., Rasmussen, A. L., Robertson, D. L., Crits-Christoph, A., Wertheim, J. O., Anthony, S. J., Barclay, W. S., Boni, M. F., Doherty, P. C., Farrar, J., Geoghegan, J. L., Jiang, X., Leibowitz, J. L., Neil, S. J. D., Skern, T., Weiss, S. R., Worobey, M., Andersen, K. G., ... Rambaut, A. (2021). The origins of SARS-CoV-2: A critical review. Cell, 184(19), 4848-4856. https://doi.org/10.1016/j.cell.2021.08.017

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title = "The origins of SARS-CoV-2: A critical review",

abstract = "Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a “laboratory escape” scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.",

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author = "Holmes, {Edward C.} and Goldstein, {Stephen A.} and Rasmussen, {Angela L.} and Robertson, {David L.} and Alexander Crits-Christoph and Wertheim, {Joel O.} and Anthony, {Simon J.} and Barclay, {Wendy S.} and Boni, {Maciej F.} and Doherty, {Peter C.} and Jeremy Farrar and Geoghegan, {Jemma L.} and Xiaowei Jiang and Leibowitz, {Julian L.} and Neil, {Stuart J.D.} and Tim Skern and Weiss, {Susan R.} and Michael Worobey and Andersen, {Kristian G.} and Garry, {Robert F.} and Andrew Rambaut",

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year = "2021",

month = sep,

day = "16",

doi = "10.1016/j.cell.2021.08.017",

language = "English",

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Holmes, EC, Goldstein, SA, Rasmussen, AL, Robertson, DL, Crits-Christoph, A, Wertheim, JO, Anthony, SJ, Barclay, WS, Boni, MF, Doherty, PC, Farrar, J, Geoghegan, JL, Jiang, X, Leibowitz, JL, Neil, SJD, Skern, T, Weiss, SR, Worobey, M, Andersen, KG, Garry, RF & Rambaut, A 2021, 'The origins of SARS-CoV-2: A critical review', Cell, vol. 184, no. 19, pp. 4848-4856. https://doi.org/10.1016/j.cell.2021.08.017

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AU - Goldstein, Stephen A.

AU - Rasmussen, Angela L.

AU - Robertson, David L.

AU - Crits-Christoph, Alexander

AU - Wertheim, Joel O.

AU - Anthony, Simon J.

AU - Barclay, Wendy S.

AU - Boni, Maciej F.

AU - Doherty, Peter C.

AU - Farrar, Jeremy

AU - Geoghegan, Jemma L.

AU - Jiang, Xiaowei

AU - Leibowitz, Julian L.

AU - Neil, Stuart J.D.

AU - Skern, Tim

AU - Weiss, Susan R.

AU - Worobey, Michael

AU - Andersen, Kristian G.

AU - Garry, Robert F.

AU - Rambaut, Andrew

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KW - origins

KW - zoonosis

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The origins of SARS-CoV-2: A critical review

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