Abstract
Aim: To clarify the effectiveness and safety of x-ray-activated photodynamic therapy (X-PDT) for cutaneous squamous cell carcinoma (SCC) and melanoma. Materials & methods: Copper-cysteamine nanoparticles were used as a photosensitizer of X-PDT. The dark toxicity and cytotoxicity were studied in vitro. Tumor volume, microvessel density and acute toxicity of mice were evaluated in vivo. Results: Without x-ray irradiation, copper-cysteamine nanoparticles were nontoxic for keratinocyte cells. XL50 cells (SCC) were more sensitive to X-PDT than B16F10 cells (melanoma). X-PDT successfully inhibited the growth of SCC in vivo (p < 0.05), while the B16F10 melanoma was resistant. Microvessel density in SCC tissue was remarkably reduced (p < 0.05). No obvious acute toxicity reaction was observed. Conclusion: X-PDT is a safe and effective treatment for SCC.
Original language | English |
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Pages (from-to) | 2027-2043 |
Number of pages | 17 |
Journal | Nanomedicine |
Volume | 14 |
Issue number | 15 |
DOIs | |
Publication status | Published - 2019 |
Externally published | Yes |
Keywords
- copper-cysteamine nanoparticle
- melanoma
- microvessel density
- photodynamic therapy
- squamous cell carcinoma (SCC)
- x-ray