The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis

J. Park; S. Kunjibettu; S. B. McMahon; M. D. Cole

doi:10.1101/gad.900101

The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis

J. Park, S. Kunjibettu, S. B. McMahon, M. D. Cole^*

^*Corresponding author for this work

Princeton University

Research output: Contribution to journal › Article › peer-review

108 Citations (Scopus)

Abstract

The ATM-related TRRAP protein is a component of several different histone acetyltransferase (HAT) complexes but lacks the kinase activity characteristic of other ATM family members. We identified a novel function for this evolutionarily conserved domain in its requirement for the assembly of a functional HAT complex. Ectopic expression of TRRAP protein with a mutation in the ATM-related domain inhibits Myc-mediated oncogenic transformation. The Myc-binding region of TRRAP maps to a separable domain, and ectopic expression of this domain inhibits cell growth. These findings demonstrate that the ATM-related domain of TRRAP forms a structural core for the assembly and recruitment of HAT complexes by transcriptional activators.

Original language	English
Pages (from-to)	1619-1624
Number of pages	6
Journal	Genes and Development
Volume	15
Issue number	13
DOIs	https://doi.org/10.1101/gad.900101
Publication status	Published - 1 Jul 2001
Externally published	Yes

Keywords

ATM domain
Histone acetyltransferase
Myc
Oncogenesis
TRRAP

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abstract = "The ATM-related TRRAP protein is a component of several different histone acetyltransferase (HAT) complexes but lacks the kinase activity characteristic of other ATM family members. We identified a novel function for this evolutionarily conserved domain in its requirement for the assembly of a functional HAT complex. Ectopic expression of TRRAP protein with a mutation in the ATM-related domain inhibits Myc-mediated oncogenic transformation. The Myc-binding region of TRRAP maps to a separable domain, and ectopic expression of this domain inhibits cell growth. These findings demonstrate that the ATM-related domain of TRRAP forms a structural core for the assembly and recruitment of HAT complexes by transcriptional activators.",

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AU - McMahon, S. B.

AU - Cole, M. D.

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AB - The ATM-related TRRAP protein is a component of several different histone acetyltransferase (HAT) complexes but lacks the kinase activity characteristic of other ATM family members. We identified a novel function for this evolutionarily conserved domain in its requirement for the assembly of a functional HAT complex. Ectopic expression of TRRAP protein with a mutation in the ATM-related domain inhibits Myc-mediated oncogenic transformation. The Myc-binding region of TRRAP maps to a separable domain, and ectopic expression of this domain inhibits cell growth. These findings demonstrate that the ATM-related domain of TRRAP forms a structural core for the assembly and recruitment of HAT complexes by transcriptional activators.

KW - ATM domain

KW - Histone acetyltransferase

KW - Myc

KW - Oncogenesis

KW - TRRAP

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JO - Genes and Development

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ER -

The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis

Abstract

Keywords

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