Abstract
Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear vitamin D receptor. Here, we report that aging nuclear vitamin D receptor knockout mice demonstrate a symmetric thalamic calcification with numerous Ca/P-containing laminated bodies. These results are consistent with clinical findings showing brain calcification in patients with vitamin D deficiency. Our results suggest that nuclear vitamin D receptor deficiency leads to brain mineralization in vitamin D receptor knockout mice, which may represent an experimental model of intracranial calcification.
Original language | English |
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Pages (from-to) | 717-721 |
Number of pages | 5 |
Journal | NeuroReport |
Volume | 17 |
Issue number | 7 |
DOIs | |
Publication status | Published - May 2006 |
Externally published | Yes |
Keywords
- Knockout mice
- Laminated bodies
- Thalamic calcification
- Vitamin D receptors