Synthetic polymers for simultaneous bacterial sequestration and quorum sense interference

Xuan Xue; George Pasparakis; Nigel Halliday; Klaus Winzer; Steven M. Howdle; Christopher J. Cramphorn; Neil R. Cameron; Paul M. Gardner; Benjamin G. Davis; Francisco Fernández-Trillo; Cameron Alexander

doi:10.1002/anie.201103130

Synthetic polymers for simultaneous bacterial sequestration and quorum sense interference

Xuan Xue, George Pasparakis, Nigel Halliday, Klaus Winzer, Steven M. Howdle, Christopher J. Cramphorn, Neil R. Cameron, Paul M. Gardner, Benjamin G. Davis^*, Francisco Fernández-Trillo, Cameron Alexander

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Double agents: Dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.

Original language	English
Pages (from-to)	9852-9856
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	42
DOIs	https://doi.org/10.1002/anie.201103130
Publication status	Published - 10 Oct 2011
Externally published	Yes

Keywords

cell adhesion
luminescence
polymers
quorum sensing
therapeutics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201103130

Cite this

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abstract = "Double agents: Dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.",

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AU - Xue, Xuan

AU - Pasparakis, George

AU - Halliday, Nigel

AU - Winzer, Klaus

AU - Howdle, Steven M.

AU - Cramphorn, Christopher J.

AU - Cameron, Neil R.

AU - Gardner, Paul M.

AU - Davis, Benjamin G.

AU - Fernández-Trillo, Francisco

AU - Alexander, Cameron

PY - 2011/10/10

Y1 - 2011/10/10

N2 - Double agents: Dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.

AB - Double agents: Dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.

KW - cell adhesion

KW - luminescence

KW - polymers

KW - quorum sensing

KW - therapeutics

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JF - Angewandte Chemie - International Edition

IS - 42

ER -

Synthetic polymers for simultaneous bacterial sequestration and quorum sense interference

Abstract

Keywords

UN SDGs

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