Synthesis and chemical transformations of 3-acetyl-4-hydroxyquinolin-2(1H)-one and its N-substituted derivatives: bird’s eye view

Moaz M. Abdou*, Zeynel Seferoğlu, Mahmoud Fathy, Takashiro Akitsu, Mamoru Koketsu, Ruba Kellow, Eric Amigues

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)


The chemistry of 3-acetyl-4-hydroxyquinolin-2(1H)-ones has attracted increased attention in both synthetic organic and medicinal chemistry, as numerous advancements in the use of this family of important compounds seems to be of considerable value. This account summarizes the results from the literature focusing on synthesis of 3-acetyl-4-hydroxyquinolin-2(1H)-ones as well as their reactions are also discussed.

Original languageEnglish
Pages (from-to)919-934
Number of pages16
JournalResearch on Chemical Intermediates
Issue number3
Publication statusPublished - 15 Mar 2019


  • 3-Acetyl-4-hydroxyquinolin-2(1H)-one
  • Chemical reactivity
  • Condensation
  • Cyclization
  • Heterocycles
  • Synthesis

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