Synaptotagmin-1: A Multi-Functional Protein that Mediates Vesicle Docking, Priming, and Fusion

Najeeb Ullah, Ezzouhra El Maaiden, Md Sahab Uddin*, Ghulam Md. Ashraf

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The fusion of secretory vesicles with the plasma membrane depends on the assembly of v-SNAREs (VAMP2/synaptobrevin2) and t-SNAREs (SNAP25/syntaxinl) into the SNARE complex. Vesicles go through several upstream steps, referred to as docking and priming, to gain fusion competence. The vesicular protein synaptotagmin-1 (Syt-1) is the principal Ca2+ sensor for fusion in several central nervous system neurons and neuroendocrine cells and part of the docking complex for secretory granules. Syt-1 binds to the acceptor complex such as synaxin1, SNAP-25 on the plasma membrane to facilitate secretory vesicle docking, and upon Ca2+-influx, it promotes vesicle fusion. This review assesses the role of the Syt-1 protein involved in the secretory vesicle docking, priming, and fusion.

Original languageEnglish
Pages (from-to)470-478
Number of pages9
JournalCurrent Protein and Peptide Science
Volume22
Issue number6
DOIs
Publication statusPublished - 2021
Externally publishedYes

Keywords

  • Exocytosis
  • Fusion
  • Priming
  • Secretory vesicles
  • Synaptotagmin-1
  • Vesicle docking

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