TY - JOUR
T1 - Surface Coordination of Black Phosphorus with Modified Cisplatin
AU - Zhang, Jianing
AU - Ma, Yue
AU - Hu, Kuan
AU - Feng, Yuan
AU - Chen, Si
AU - Yang, Xiaoyang
AU - Fong-Chuen Loo, Jacky
AU - Zhang, Han
AU - Yin, Feng
AU - Li, Zigang
N1 - Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/6/19
Y1 - 2019/6/19
N2 - Black phosphorus (BP) is a two-dimensional (2D) nanomaterial with high charge-carrier mobility, a tunable direct bandgap, and a unique in-plane anisotropic structure; however, the easiness of BP oxidation into PxOy species in ambient conditions largely limits its applications. In this study, modified cisplatin-Pt-NO3 [Pt(NH3)2(NO3)2] is used for surface coordination with BP nanosheets to generate Pt@BP, which maintains the surface morphology and properties of BP nanosheets for more than 24 h in ambient conditions. In addition, Pt@BP interacts with DNA both in vitro and in cell. Pt@BP shows a good cellular uptake rate and significantly increases the drug sensitivity of cisplatin-resistant cancer cell lines (A2780 and HepG2) compared with unmodified cisplatin. Our study is the first attempt to stabilize bare BP with cationic cisplatin species, and the generated Pt@BP could be used for potential synergistic photothermal/chemotherapy of cisplatin-resistant cancer.
AB - Black phosphorus (BP) is a two-dimensional (2D) nanomaterial with high charge-carrier mobility, a tunable direct bandgap, and a unique in-plane anisotropic structure; however, the easiness of BP oxidation into PxOy species in ambient conditions largely limits its applications. In this study, modified cisplatin-Pt-NO3 [Pt(NH3)2(NO3)2] is used for surface coordination with BP nanosheets to generate Pt@BP, which maintains the surface morphology and properties of BP nanosheets for more than 24 h in ambient conditions. In addition, Pt@BP interacts with DNA both in vitro and in cell. Pt@BP shows a good cellular uptake rate and significantly increases the drug sensitivity of cisplatin-resistant cancer cell lines (A2780 and HepG2) compared with unmodified cisplatin. Our study is the first attempt to stabilize bare BP with cationic cisplatin species, and the generated Pt@BP could be used for potential synergistic photothermal/chemotherapy of cisplatin-resistant cancer.
UR - http://www.scopus.com/inward/record.url?scp=85067449861&partnerID=8YFLogxK
U2 - 10.1021/acs.bioconjchem.9b00128
DO - 10.1021/acs.bioconjchem.9b00128
M3 - Article
C2 - 31070357
AN - SCOPUS:85067449861
SN - 1043-1802
VL - 30
SP - 1658
EP - 1664
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
IS - 6
ER -
