Sensing of triglyceride concentration in blood solution using photoacoustic microscopy

Nan Wan; Zhe Li; Myeongsu Seong; Ke Zhang; Wei Niu; Rong Wu; Sung Liang Chen

doi:10.1364/OL.485194

Sensing of triglyceride concentration in blood solution using photoacoustic microscopy

Nan Wan, Zhe Li, Myeongsu Seong, Ke Zhang, Wei Niu, Rong Wu, Sung Liang Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The level of triglyceride (TG) in blood is essential to human health, and hypertriglyceridemia (TG level > 150 mg/dL) would lead to cardiovascular disease and acute pancreatitis that threaten human life. Routine methods for measuring the TG level in blood depend on a lipid panel blood test, which is invasive and not convenient. Here, we use photoacoustic (PA) microscopy to test the PA amplitude of blood solutions (based on hemoglobin powder as well as flowing sheep blood) with different TG concentrations. Interestingly, we observe that the PA amplitude increases with increasing TG concentration in blood solutions, which is attributed to the increase of the Grüneisen coefficient. The preliminary in vitro study shows that the PA methodology is able to detect the TG level down to 450 mg/dL. This finding provides an opportunity for using photoacoustics to noninvasively diagnose hypertriglyceridemia.

Original language	English
Pages (from-to)	3769-3772
Number of pages	4
Journal	Optics Letters
Volume	48
Issue number	14
DOIs	https://doi.org/10.1364/OL.485194
Publication status	Published - 2023
Externally published	Yes

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title = "Sensing of triglyceride concentration in blood solution using photoacoustic microscopy",

abstract = "The level of triglyceride (TG) in blood is essential to human health, and hypertriglyceridemia (TG level > 150 mg/dL) would lead to cardiovascular disease and acute pancreatitis that threaten human life. Routine methods for measuring the TG level in blood depend on a lipid panel blood test, which is invasive and not convenient. Here, we use photoacoustic (PA) microscopy to test the PA amplitude of blood solutions (based on hemoglobin powder as well as flowing sheep blood) with different TG concentrations. Interestingly, we observe that the PA amplitude increases with increasing TG concentration in blood solutions, which is attributed to the increase of the Gr{\"u}neisen coefficient. The preliminary in vitro study shows that the PA methodology is able to detect the TG level down to 450 mg/dL. This finding provides an opportunity for using photoacoustics to noninvasively diagnose hypertriglyceridemia.",

author = "Nan Wan and Zhe Li and Myeongsu Seong and Ke Zhang and Wei Niu and Rong Wu and Chen, {Sung Liang}",

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doi = "10.1364/OL.485194",

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T1 - Sensing of triglyceride concentration in blood solution using photoacoustic microscopy

AU - Wan, Nan

AU - Li, Zhe

AU - Seong, Myeongsu

AU - Zhang, Ke

AU - Niu, Wei

AU - Wu, Rong

AU - Chen, Sung Liang

PY - 2023

Y1 - 2023

N2 - The level of triglyceride (TG) in blood is essential to human health, and hypertriglyceridemia (TG level > 150 mg/dL) would lead to cardiovascular disease and acute pancreatitis that threaten human life. Routine methods for measuring the TG level in blood depend on a lipid panel blood test, which is invasive and not convenient. Here, we use photoacoustic (PA) microscopy to test the PA amplitude of blood solutions (based on hemoglobin powder as well as flowing sheep blood) with different TG concentrations. Interestingly, we observe that the PA amplitude increases with increasing TG concentration in blood solutions, which is attributed to the increase of the Grüneisen coefficient. The preliminary in vitro study shows that the PA methodology is able to detect the TG level down to 450 mg/dL. This finding provides an opportunity for using photoacoustics to noninvasively diagnose hypertriglyceridemia.

AB - The level of triglyceride (TG) in blood is essential to human health, and hypertriglyceridemia (TG level > 150 mg/dL) would lead to cardiovascular disease and acute pancreatitis that threaten human life. Routine methods for measuring the TG level in blood depend on a lipid panel blood test, which is invasive and not convenient. Here, we use photoacoustic (PA) microscopy to test the PA amplitude of blood solutions (based on hemoglobin powder as well as flowing sheep blood) with different TG concentrations. Interestingly, we observe that the PA amplitude increases with increasing TG concentration in blood solutions, which is attributed to the increase of the Grüneisen coefficient. The preliminary in vitro study shows that the PA methodology is able to detect the TG level down to 450 mg/dL. This finding provides an opportunity for using photoacoustics to noninvasively diagnose hypertriglyceridemia.

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Sensing of triglyceride concentration in blood solution using photoacoustic microscopy

Abstract

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