TY - JOUR
T1 - Novel and robust auxiliary indicators to ankle-brachial index using multi-site pulse arrival time and detrended fluctuation analysis for peripheral arterial disease assessment
AU - Geng, Guoqiang
AU - Zheng, Yali
AU - Hong, Jingyuan
AU - Liu, Qing
AU - Poon, Carmen C.Y.
N1 - Funding Information:
This work was supported by Shenzhen Fundamental Research Program [JCYJ20190813111001769], Guangdong Basic and Applied Basic Research Foundation [ 2021A1515110025 ], Natural Science Foundation of Top Talent of SZTU [ 2020110 ], Shenzhen Pengcheng Scholar Program and Natural Science Foundation of the Jiangsu Higher Education Institutions of China [ 18KJB416007 ]. The authors would like to acknowledge Professor James Y.W. Lau, Division of Vascular and General Surgery, Department of Surgery; and Professor Bryan P. Y. Yan, Division of Cardiology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong for their help in collecting the data used in this study.
Funding Information:
This work was supported by Shenzhen Fundamental Research Program [JCYJ20190813111001769], Guangdong Basic and Applied Basic Research Foundation [2021A1515110025], Natural Science Foundation of Top Talent of SZTU [2020110], Shenzhen Pengcheng Scholar Program and Natural Science Foundation of the Jiangsu Higher Education Institutions of China [18KJB416007]. The authors would like to acknowledge Professor James Y.W. Lau, Division of Vascular and General Surgery, Department of Surgery; and Professor Bryan P. Y. Yan, Division of Cardiology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong for their help in collecting the data used in this study.
Publisher Copyright:
© 2022 The Author(s)
PY - 2022/8
Y1 - 2022/8
N2 - The ankle-brachial index (ABI) test is a common tool used for screening peripheral arterial disease (PAD), but its accuracy has been doubted especially in patients with incompressible arteries attributed to calcification. Advanced wearable sensing technologies have potential to offer novel solutions for PAD assessment. This study investigated several novel indicators using the Detrended Fluctuation Analysis (DFA) on beat-to-beat RR interval (RRI) and pulse arrival time (PAT) from the four limbs of 7 young healthy and 7 elderly PAD subjects in supine and sitting postures. The auxiliary value of these indicators in addition to ABI for PAD assessment was also studied using a binary logistic regression model. The results showed that the short-scale DFA coefficients (α1) of RRI, α1 of PATs of fingers and α1_ratio of PAT (the ratio of α1 of PAT between the ipsilateral finger and toe) in supine posture, were significantly different between the PAD and healthy groups (1.26 ± 0.24 vs 0.76 ± 0.21, 1.03 ± 0.30 vs 0.68 ± 0.19, and 0.84 ± 0.20 vs 1.42 ± 0.47, respectively, p < 0.05), and the α1 of RRI and α1_ratio of PAT were not significantly influenced by postural change. Moreover, using ABI together with the supine α1_ratio of PAT was more sensitive in detecting PAD (sensitivity = 92.9%) than ABI alone (78.6%) with the same specificity of 100%. The short-scale DFA coefficients of multi-site PAT in supine posture, which can be measured by wearable devices, is an auxiliary to ABI for detecting PAD.
AB - The ankle-brachial index (ABI) test is a common tool used for screening peripheral arterial disease (PAD), but its accuracy has been doubted especially in patients with incompressible arteries attributed to calcification. Advanced wearable sensing technologies have potential to offer novel solutions for PAD assessment. This study investigated several novel indicators using the Detrended Fluctuation Analysis (DFA) on beat-to-beat RR interval (RRI) and pulse arrival time (PAT) from the four limbs of 7 young healthy and 7 elderly PAD subjects in supine and sitting postures. The auxiliary value of these indicators in addition to ABI for PAD assessment was also studied using a binary logistic regression model. The results showed that the short-scale DFA coefficients (α1) of RRI, α1 of PATs of fingers and α1_ratio of PAT (the ratio of α1 of PAT between the ipsilateral finger and toe) in supine posture, were significantly different between the PAD and healthy groups (1.26 ± 0.24 vs 0.76 ± 0.21, 1.03 ± 0.30 vs 0.68 ± 0.19, and 0.84 ± 0.20 vs 1.42 ± 0.47, respectively, p < 0.05), and the α1 of RRI and α1_ratio of PAT were not significantly influenced by postural change. Moreover, using ABI together with the supine α1_ratio of PAT was more sensitive in detecting PAD (sensitivity = 92.9%) than ABI alone (78.6%) with the same specificity of 100%. The short-scale DFA coefficients of multi-site PAT in supine posture, which can be measured by wearable devices, is an auxiliary to ABI for detecting PAD.
KW - Ankle-brachial index
KW - Detrended fluctuation analysis
KW - Peripheral arterial disease
KW - Pulse arrival time
UR - http://www.scopus.com/inward/record.url?scp=85131821240&partnerID=8YFLogxK
U2 - 10.1016/j.bspc.2022.103865
DO - 10.1016/j.bspc.2022.103865
M3 - Article
AN - SCOPUS:85131821240
SN - 1746-8094
VL - 77
JO - Biomedical Signal Processing and Control
JF - Biomedical Signal Processing and Control
M1 - 103865
ER -