Abstract
Grooming is an important part of rodent behavioural repertoire, representing a complex hierarchically ordered cephalo-caudal sequence of patterns sensitive to stress and various drugs. Gamma-aminobutyric acid (GABA) is involved in the regulation of both anxiety and grooming behaviours. This study investigated the predictive validity of grooming behavioural microstructure as a marker of anxiety, by examining the effects of two GABAergic reference compounds, anxiolytic diazepam (0.1 and 0.5 mg/kg i.p.) and anxiogenic pentylenetetrazole (5 and 10 mg/kg i.p.) on mouse grooming. Our data suggest that the percentage of pattern transitions not fitting to the cephalo-caudal progression, and the percentage of interrupted grooming bouts are more reliable behavioural markers of stress bidirectionally sensitive to GABAergic anxiogenic and anxiolytic drugs, compared to the frequency and duration scores. Our study also confirms that detailed ethological analyses of grooming microstructure can be a useful tool in behavioural pharmacology of anxiety.
| Original language | English |
|---|---|
| Pages (from-to) | 147-153 |
| Number of pages | 7 |
| Journal | European Journal of Pharmacology |
| Volume | 508 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - 31 Jan 2005 |
| Externally published | Yes |
Keywords
- Anxiety
- Diazepam
- GABA
- Grooming behaviour
- Mice
- Pentylenetetrazole