TY - JOUR
T1 - Modeling depression in zebrafish
AU - Galstyan, David S.
AU - Kolesnikova, Tatyana O.
AU - Kositsyn, Yurii M.
AU - Zabegalov, Konstantin N.
AU - Gubaidullina, Mariya A.
AU - Maslov, Gleb O.
AU - Demin, Konstantin A.
AU - Khatsko, Sergey L.
AU - Kalueff, Allan V.
N1 - Publisher Copyright:
© Authors, 2022.
PY - 2022
Y1 - 2022
N2 - Depression is a widespread, severely debilitating mental disorder characterized by low mood, anhedonia, fatigue, decreased attention, suicidality and psychomotor retardation, accompanied by neuroendocrine and molecular disorders. Zebrafish have neuroendocrine and neurotransmitter systems similar to humans, as well as high genetic homology, and are rapidly becoming popular model organisms for modeling depressive-like conditions. Here, we discuss modern behavioral, pharmacological and genetic models of depression in zebrafish, their methodological applications and translational implications.
AB - Depression is a widespread, severely debilitating mental disorder characterized by low mood, anhedonia, fatigue, decreased attention, suicidality and psychomotor retardation, accompanied by neuroendocrine and molecular disorders. Zebrafish have neuroendocrine and neurotransmitter systems similar to humans, as well as high genetic homology, and are rapidly becoming popular model organisms for modeling depressive-like conditions. Here, we discuss modern behavioral, pharmacological and genetic models of depression in zebrafish, their methodological applications and translational implications.
KW - chronic stress
KW - depression
KW - despair
KW - reserpine
KW - zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85166761063&partnerID=8YFLogxK
U2 - 10.17816/RCF202149-156
DO - 10.17816/RCF202149-156
M3 - Article
AN - SCOPUS:85166761063
SN - 1683-4100
VL - 20
SP - 149
EP - 156
JO - Reviews on Clinical Pharmacology and Drug Therapy
JF - Reviews on Clinical Pharmacology and Drug Therapy
IS - 2
ER -
