Iron-based magnetic nanoparticles for multimodal hyperthermia heating

M. Xing, Jeotikanta Mohapatra, J. Beatty, J. Elkins, Nil Kanatha Pandey, A. Chalise, W. Chen, M. Jin, J. Ping Liu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Localized heat generation using nanoparticles is a promising supplementary technique to the well-established cancer treatments, such as chemotherapy and radiotherapy. Here, we demonstrate that iron carbide (Fe5C2) nanoparticles with a thin carbon shell have the collective magnetothermal and photothermal effects based on the ferromagnetic and photonic properties. When the Fe5C2 nanoparticle suspension is irradiated with a NIR laser (808 nm), it yields unprecedented heating effects. Further, owing to the observed high magnetization and coercivity, the Fe5C2 nanoparticle suspension on exposure to an alternating magnetic field (ACMF) exhibits an enhanced specific absorption rate (SAR) as compared to Fe3O4 nanoparticles of the same size. This significant improvement in the SAR arises from the cooperative contribution from the hysteresis and susceptibility losses. This work also gives quantitative information about the ACMF effects on heating ability as well as provides some guidelines for obtaining enhanced heating activity in nanoparticle suspensions of a given magnetic material.

Original languageEnglish
Article number159475
JournalJournal of Alloys and Compounds
Publication statusPublished - 5 Aug 2021
Externally publishedYes


  • Hyperthermia therapy
  • Magnetic hyperthermia
  • Magnetic nanoparticles
  • Photothermal therapy


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