Genetic animal models of depression

Peter R. Canavello, Rupert J. Egan, Carisa L. Bergner, Peter C. Hart, Jonathan M. Cachat, Allan V. Kalueff

Research output: Chapter in Book or Report/Conference proceedingChapterpeer-review

6 Citations (Scopus)


Depression, as part of a larger class of affective disorders, is one of the world's most deleterious and widespread neurobehavioral diseases. However, much remains to be discovered concerning depression, due to the daunting complexity of its pathological mechanisms and etiology. Various animal models have been proposed over the years, some of which have come into widespread use, particularly in the area of pharmacological screening. By combining behavioral and physiological analyses with mutant and transgenic animal models, researchers are able to determine the role of specific genes and proteins in the pathogenesis of depression. Discussing several behavioral and transgenic/mutant rodent models, this chapter briefly summarizes the current progress in this area of psychiatric research.

Original languageEnglish
Title of host publicationTransgenic and Mutant Tools to Model Brain Disorders
EditorsAllan V. Kalueff, Carisa L. Bergner
Number of pages10
Publication statusPublished - 2010
Externally publishedYes

Publication series

ISSN (Print)0893-2336
ISSN (Electronic)1940-6045


  • Anhedonia
  • Behavioral despair
  • Depression
  • Learned helplessnes


Dive into the research topics of 'Genetic animal models of depression'. Together they form a unique fingerprint.

Cite this