TY - JOUR
T1 - Exposure to secondhand tobacco smoke and lung cancer by histological type
T2 - A pooled analysis of the International Lung Cancer Consortium (ILCCO)
AU - Kim, Claire H.
AU - Lee, Yuan Chin Amy
AU - Hung, Rayjean J.
AU - McNallan, Sheila R.
AU - Cote, Michele L.
AU - Lim, Wei Yen
AU - Chang, Shen Chih
AU - Kim, Jin Hee
AU - Ugolini, Donatella
AU - Chen, Ying
AU - Liloglou, Triantafillos
AU - Andrew, Angeline S.
AU - Onega, Tracy
AU - Duell, Eric J.
AU - Field, John K.
AU - Lazarus, Philip
AU - Le Marchand, Loic
AU - Neri, Monica
AU - Vineis, Paolo
AU - Kiyohara, Chikako
AU - Hong, Yun Chul
AU - Morgenstern, Hal
AU - Matsuo, Keitaro
AU - Tajima, Kazuo
AU - Christiani, David C.
AU - McLaughlin, John R.
AU - Bencko, Vladimir
AU - Holcatova, Ivana
AU - Boffetta, Paolo
AU - Brennan, Paul
AU - Fabianova, Eleonora
AU - Foretova, Lenka
AU - Janout, Vladimir
AU - Lissowska, Jolanta
AU - Mates, Dana
AU - Rudnai, Peter
AU - Szeszenia-Dabrowska, Neonila
AU - Mukeria, Anush
AU - Zaridze, David
AU - Seow, Adeline
AU - Schwartz, Ann G.
AU - Yang, Ping
AU - Zhang, Zuo Feng
PY - 2014/10/15
Y1 - 2014/10/15
N2 - While the association between exposure to secondhand smoke and lung cancer risk is well established, few studies with sufficient power have examined the association by histological type. In this study, we evaluated the secondhand smoke-lung cancer relationship by histological type based on pooled data from 18 case-control studies in the International Lung Cancer Consortium (ILCCO), including 2,504 cases and 7,276 control who were never smokers and 10,184 cases and 7,176 controls who were ever smokers. We used multivariable logistic regression, adjusting for age, sex, race/ethnicity, smoking status, pack-years of smoking, and study. Among never smokers, the odds ratios (OR) comparing those ever exposed to secondhand smoke with those never exposed were 1.31 (95% CI: 1.17-1.45) for all histological types combined, 1.26 (95% CI: 1.10-1.44) for adenocarcinoma, 1.41 (95% CI: 0.99-1.99) for squamous cell carcinoma, 1.48 (95% CI: 0.89-2.45) for large cell lung cancer, and 3.09 (95% CI: 1.62-5.89) for small cell lung cancer. The estimated association with secondhand smoke exposure was greater for small cell lung cancer than for nonsmall cell lung cancers (OR=2.11, 95% CI: 1.11-4.04). This analysis is the largest to date investigating the relation between exposure to secondhand smoke and lung cancer. Our study provides more precise estimates of the impact of secondhand smoke on the major histological types of lung cancer, indicates the association with secondhand smoke is stronger for small cell lung cancer than for the other histological types, and suggests the importance of intervention against exposure to secondhand smoke in lung cancer prevention.
AB - While the association between exposure to secondhand smoke and lung cancer risk is well established, few studies with sufficient power have examined the association by histological type. In this study, we evaluated the secondhand smoke-lung cancer relationship by histological type based on pooled data from 18 case-control studies in the International Lung Cancer Consortium (ILCCO), including 2,504 cases and 7,276 control who were never smokers and 10,184 cases and 7,176 controls who were ever smokers. We used multivariable logistic regression, adjusting for age, sex, race/ethnicity, smoking status, pack-years of smoking, and study. Among never smokers, the odds ratios (OR) comparing those ever exposed to secondhand smoke with those never exposed were 1.31 (95% CI: 1.17-1.45) for all histological types combined, 1.26 (95% CI: 1.10-1.44) for adenocarcinoma, 1.41 (95% CI: 0.99-1.99) for squamous cell carcinoma, 1.48 (95% CI: 0.89-2.45) for large cell lung cancer, and 3.09 (95% CI: 1.62-5.89) for small cell lung cancer. The estimated association with secondhand smoke exposure was greater for small cell lung cancer than for nonsmall cell lung cancers (OR=2.11, 95% CI: 1.11-4.04). This analysis is the largest to date investigating the relation between exposure to secondhand smoke and lung cancer. Our study provides more precise estimates of the impact of secondhand smoke on the major histological types of lung cancer, indicates the association with secondhand smoke is stronger for small cell lung cancer than for the other histological types, and suggests the importance of intervention against exposure to secondhand smoke in lung cancer prevention.
KW - International Lung Cancer Consortium
KW - environmental tobacco smoke
KW - involuntary smoking
KW - lung cancer
KW - secondhand smoke
UR - http://www.scopus.com/inward/record.url?scp=84905723260&partnerID=8YFLogxK
U2 - 10.1002/ijc.28835
DO - 10.1002/ijc.28835
M3 - Article
C2 - 24615328
AN - SCOPUS:84905723260
SN - 0020-7136
VL - 135
SP - 1918
EP - 1930
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 8
ER -