TY - JOUR
T1 - Exposure to environmental microbiota explains persistent abdominal pain and irritable bowel syndrome after a major flood
AU - Yusof, Nurfadhilah
AU - Hamid, Nurhazwani
AU - Ma, Zheng Feei
AU - Lawenko, Rona Marie
AU - Wan Mohammad, Wan Mohd Zahiruddin
AU - Collins, Deirdre A.
AU - Liong, Min Tze
AU - Odamaki, Toshitaka
AU - Xiao, Jinzhong
AU - Lee, Yeong Yeh
N1 - Funding Information:
The research was supported by the Fundamental Research Grant Scheme of Ministry of Education of Malaysia (References: 203.PPSP.6171183 and 203. PPSP.6171192). Also supported the study was the Morinaga Milk Industry Co., Ltd., Japan. However, the funders had no roles in the study design or influence the final results.
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/12/14
Y1 - 2017/12/14
N2 - Background: After an environmental disaster, the affected community is at increased risk for persistent abdominal pain but mechanisms are unclear. Therefore, our study aimed to determine association between abdominal pain and poor water, sanitation and hygiene (WaSH) practices, and if small intestinal bacterial overgrowth (SIBO) and/or gut dysbiosis explain IBS, impaired quality of life (QOL), anxiety and/or depression after a major flood. Results: New onset abdominal pain, IBS based on the Rome III criteria, WaSH practices, QOL, anxiety and/or depression, SIBO (hydrogen breath testing) and stools for metagenomic sequencing were assessed in flood victims. Of 211 participants, 37.9% (n = 80) had abdominal pain and 17% (n = 36) with IBS subtyped diarrhea and/or mixed type (n = 27 or 12.8%) being the most common. Poor WaSH practices and impaired quality of life during flood were significantly associated with IBS. Using linear discriminant analysis effect size method, gut dysbiosis was observed in those with anxiety (Bacteroidetes and Proteobacteria, effect size 4.8), abdominal pain (Fusobacteria, Staphylococcus, Megamonas and Plesiomonas, effect size 4.0) and IBS (Plesiomonas and Trabulsiella, effect size 3.0). Conclusion: Disturbed gut microbiota because of environmentally-derived organisms may explain persistent abdominal pain and IBS after a major environmental disaster in the presence of poor WaSH practices.
AB - Background: After an environmental disaster, the affected community is at increased risk for persistent abdominal pain but mechanisms are unclear. Therefore, our study aimed to determine association between abdominal pain and poor water, sanitation and hygiene (WaSH) practices, and if small intestinal bacterial overgrowth (SIBO) and/or gut dysbiosis explain IBS, impaired quality of life (QOL), anxiety and/or depression after a major flood. Results: New onset abdominal pain, IBS based on the Rome III criteria, WaSH practices, QOL, anxiety and/or depression, SIBO (hydrogen breath testing) and stools for metagenomic sequencing were assessed in flood victims. Of 211 participants, 37.9% (n = 80) had abdominal pain and 17% (n = 36) with IBS subtyped diarrhea and/or mixed type (n = 27 or 12.8%) being the most common. Poor WaSH practices and impaired quality of life during flood were significantly associated with IBS. Using linear discriminant analysis effect size method, gut dysbiosis was observed in those with anxiety (Bacteroidetes and Proteobacteria, effect size 4.8), abdominal pain (Fusobacteria, Staphylococcus, Megamonas and Plesiomonas, effect size 4.0) and IBS (Plesiomonas and Trabulsiella, effect size 3.0). Conclusion: Disturbed gut microbiota because of environmentally-derived organisms may explain persistent abdominal pain and IBS after a major environmental disaster in the presence of poor WaSH practices.
KW - Abdominal pain
KW - Dysbiosis
KW - Flood
KW - Malaysia
KW - Sanitation and hygiene practices
KW - Small intestinal bacterial overgrowth
KW - Water
UR - http://www.scopus.com/inward/record.url?scp=85041221719&partnerID=8YFLogxK
U2 - 10.1186/s13099-017-0224-7
DO - 10.1186/s13099-017-0224-7
M3 - Article
AN - SCOPUS:85041221719
SN - 1757-4749
VL - 9
JO - Gut Pathogens
JF - Gut Pathogens
IS - 1
M1 - 75
ER -