Exploration of TiO2 nanoparticle mediated microdynamic therapy on cancer treatment

Xiao Chu, Liang Mao, Omar Johnson, Kang Li, Jonathan Phan, Qingshui Yin, Lihua Li, Junying Zhang*, Wei Chen, Yu Zhang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Radical therapy takes advantage of the reactive oxygen species produced in greater quantities within tumor cells than in normal cells. Here, for the first time, we explore a TiO2 nanoparticle mediated microwave induced radical therapy (termed as Microdynamic Therapy)as a new cancer treatment method. The experiments in vitro and in vivo demonstrate that colloidal TiO2 nanoparticles could significantly suppress the growth of osteosarcomas, even under low power (5 W)microwave (MW)irradiation for 5 min. The high photocatalytic activity of TiO2 nanoparticles efficiently utilizes the microwave-induced plasmonic effect for the formation of reactive oxygen species (ROS). Furthermore, TiO2 nanoparticles exhibit a higher cytotoxicity on cancer cells (osteosarcoma UMR-106 cells)than on normal cells (mouse fibroblast L929 cells). The effectiveness of TiO2 nanoparticles for microwave induced radical therapy demonstrates that this is a new landmark approach to treating cancers.

Original languageEnglish
Pages (from-to)272-281
Number of pages10
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume18
DOIs
Publication statusPublished - Jun 2019
Externally publishedYes

Keywords

  • Microdynamic therapy
  • Osteosarcoma
  • Reactive oxygen species
  • TiO nanoparticles

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