TY - JOUR
T1 - Exploration of TiO2 nanoparticle mediated microdynamic therapy on cancer treatment
AU - Chu, Xiao
AU - Mao, Liang
AU - Johnson, Omar
AU - Li, Kang
AU - Phan, Jonathan
AU - Yin, Qingshui
AU - Li, Lihua
AU - Zhang, Junying
AU - Chen, Wei
AU - Zhang, Yu
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/6
Y1 - 2019/6
N2 - Radical therapy takes advantage of the reactive oxygen species produced in greater quantities within tumor cells than in normal cells. Here, for the first time, we explore a TiO2 nanoparticle mediated microwave induced radical therapy (termed as Microdynamic Therapy)as a new cancer treatment method. The experiments in vitro and in vivo demonstrate that colloidal TiO2 nanoparticles could significantly suppress the growth of osteosarcomas, even under low power (5 W)microwave (MW)irradiation for 5 min. The high photocatalytic activity of TiO2 nanoparticles efficiently utilizes the microwave-induced plasmonic effect for the formation of reactive oxygen species (ROS). Furthermore, TiO2 nanoparticles exhibit a higher cytotoxicity on cancer cells (osteosarcoma UMR-106 cells)than on normal cells (mouse fibroblast L929 cells). The effectiveness of TiO2 nanoparticles for microwave induced radical therapy demonstrates that this is a new landmark approach to treating cancers.
AB - Radical therapy takes advantage of the reactive oxygen species produced in greater quantities within tumor cells than in normal cells. Here, for the first time, we explore a TiO2 nanoparticle mediated microwave induced radical therapy (termed as Microdynamic Therapy)as a new cancer treatment method. The experiments in vitro and in vivo demonstrate that colloidal TiO2 nanoparticles could significantly suppress the growth of osteosarcomas, even under low power (5 W)microwave (MW)irradiation for 5 min. The high photocatalytic activity of TiO2 nanoparticles efficiently utilizes the microwave-induced plasmonic effect for the formation of reactive oxygen species (ROS). Furthermore, TiO2 nanoparticles exhibit a higher cytotoxicity on cancer cells (osteosarcoma UMR-106 cells)than on normal cells (mouse fibroblast L929 cells). The effectiveness of TiO2 nanoparticles for microwave induced radical therapy demonstrates that this is a new landmark approach to treating cancers.
KW - Microdynamic therapy
KW - Osteosarcoma
KW - Reactive oxygen species
KW - TiO nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85064740792&partnerID=8YFLogxK
U2 - 10.1016/j.nano.2019.02.016
DO - 10.1016/j.nano.2019.02.016
M3 - Article
C2 - 30878657
AN - SCOPUS:85064740792
SN - 1549-9634
VL - 18
SP - 272
EP - 281
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
ER -