Emerging Promise of Therapeutic Approaches Targeting Mitochondria in Neurodegenerative Disorders

Md Mominur Rahman, Mst Afroza Alam Tumpa, Md Saidur Rahaman, Fahadul Islam, Popy Rani Sutradhar, Muniruddin Ahmed, Badrah S. Alghamdi, Abdul Hafeez, Athanasios Alexiou*, Asma Perveen, Ghulam Md Ashraf*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Mitochondria are critical for homeostasis and metabolism in all cellular eukaryotes. Brain mitochondria are the primary source of fuel that supports many brain functions, including intracellular energy supply, cellular calcium regulation, regulation of limited cellular oxidative capacity, and control of cell death. Much evidence suggests that mitochondria play a central role in neurodegenerative disorders (NDDs) such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyo-trophic lateral sclerosis. Ongoing studies of NDDs have revealed that mitochondrial pathology is mainly found in inherited or irregular NDDs and is thought to be associated with the pathophysiological cycle of these disorders. Typical mitochondrial disturbances in NDDs include increased free radical production, decreased ATP synthesis, alterations in mitochondrial permeability, and mitochondrial DNA damage. The main objective of this review is to highlight the basic mitochondrial problems that occur in NDDs and discuss the use mitochondrial drugs, especially mitochondrial antioxidants, mito-chondrial permeability transition blockade, and mitochondrial gene therapy, for the treatment and control of NDDs.

Original languageEnglish
Pages (from-to)1081-1099
Number of pages19
JournalCurrent Neuropharmacology
Volume21
Issue number5
DOIs
Publication statusPublished - 2023
Externally publishedYes

Keywords

  • Alzheimer’s disease
  • antioxidants
  • gene therapy
  • Mitochondria
  • neurodegenerative disorders
  • Parkinson’s disease

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