Design and Characterization of Hydroxyapatite Scaffolds Fabricated by Stereolithography for Bone Tissue Engineering Application

Zhen Wang; Chuanzhen Huang; Jun Wang; Bin Zou; Ch Asad Abbas; Xiaodan Wang

doi:10.1016/j.procir.2020.05.138

Design and Characterization of Hydroxyapatite Scaffolds Fabricated by Stereolithography for Bone Tissue Engineering Application

Zhen Wang, Chuanzhen Huang^*, Jun Wang, Bin Zou, Ch Asad Abbas, Xiaodan Wang

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › peer-review

30 Citations (Scopus)

Abstract

In this study, a novel method to design hydroxyapatite scaffold based on gradient porosity was proposed. Additionally, after a tailor-made ceramic suspension was cured by stereolithography (SLA), a minimal pore with a diameter size of 500μm can be fabricated, and it has a high dimension precision up to about 60μm. The compression test showed that the scaffolds had an effective elastic modulus ranging from 2.4GPa to 5.9GPa, which could match with the cancellous bone well. Moreover, in-vitro experiments demonstrated that this hydroxyapatite bioceramic scaffold was compatible with bone marrow mesenchymal stem cells (BMSCs) and showed good effect on cell proliferation.

Original language	English
Pages (from-to)	170-175
Number of pages	6
Journal	Procedia CIRP
Volume	89
DOIs	https://doi.org/10.1016/j.procir.2020.05.138
Publication status	Published - 2020
Externally published	Yes
Event	4th CIRP Conference on Biomanufacturing, CIRP-BioM 2019 - Guangzhou, China Duration: 12 Dec 2019 → 15 Dec 2019

Keywords

Bioceramic
Bone Scaffold
Gradient Porosity
Stereolithography

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10.1016/j.procir.2020.05.138

Cite this

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title = "Design and Characterization of Hydroxyapatite Scaffolds Fabricated by Stereolithography for Bone Tissue Engineering Application",

abstract = "In this study, a novel method to design hydroxyapatite scaffold based on gradient porosity was proposed. Additionally, after a tailor-made ceramic suspension was cured by stereolithography (SLA), a minimal pore with a diameter size of 500μm can be fabricated, and it has a high dimension precision up to about 60μm. The compression test showed that the scaffolds had an effective elastic modulus ranging from 2.4GPa to 5.9GPa, which could match with the cancellous bone well. Moreover, in-vitro experiments demonstrated that this hydroxyapatite bioceramic scaffold was compatible with bone marrow mesenchymal stem cells (BMSCs) and showed good effect on cell proliferation.",

keywords = "Bioceramic, Bone Scaffold, Gradient Porosity, Stereolithography",

author = "Zhen Wang and Chuanzhen Huang and Jun Wang and Bin Zou and Abbas, {Ch Asad} and Xiaodan Wang",

note = "Funding Information: The work is supported by National Natural Science Foundation of China (51675312) and Major Program of Shandong Province Natural Science Foundation (No. ZR2018ZA0401). Publisher Copyright: {\textcopyright} 2020 The Authors.; 4th CIRP Conference on Biomanufacturing, CIRP-BioM 2019 ; Conference date: 12-12-2019 Through 15-12-2019",

year = "2020",

doi = "10.1016/j.procir.2020.05.138",

language = "English",

volume = "89",

pages = "170--175",

journal = "Procedia CIRP",

issn = "2212-8271",

}

TY - JOUR

T1 - Design and Characterization of Hydroxyapatite Scaffolds Fabricated by Stereolithography for Bone Tissue Engineering Application

AU - Wang, Zhen

AU - Huang, Chuanzhen

AU - Wang, Jun

AU - Zou, Bin

AU - Abbas, Ch Asad

AU - Wang, Xiaodan

N1 - Funding Information: The work is supported by National Natural Science Foundation of China (51675312) and Major Program of Shandong Province Natural Science Foundation (No. ZR2018ZA0401). Publisher Copyright: © 2020 The Authors.

PY - 2020

Y1 - 2020

N2 - In this study, a novel method to design hydroxyapatite scaffold based on gradient porosity was proposed. Additionally, after a tailor-made ceramic suspension was cured by stereolithography (SLA), a minimal pore with a diameter size of 500μm can be fabricated, and it has a high dimension precision up to about 60μm. The compression test showed that the scaffolds had an effective elastic modulus ranging from 2.4GPa to 5.9GPa, which could match with the cancellous bone well. Moreover, in-vitro experiments demonstrated that this hydroxyapatite bioceramic scaffold was compatible with bone marrow mesenchymal stem cells (BMSCs) and showed good effect on cell proliferation.

AB - In this study, a novel method to design hydroxyapatite scaffold based on gradient porosity was proposed. Additionally, after a tailor-made ceramic suspension was cured by stereolithography (SLA), a minimal pore with a diameter size of 500μm can be fabricated, and it has a high dimension precision up to about 60μm. The compression test showed that the scaffolds had an effective elastic modulus ranging from 2.4GPa to 5.9GPa, which could match with the cancellous bone well. Moreover, in-vitro experiments demonstrated that this hydroxyapatite bioceramic scaffold was compatible with bone marrow mesenchymal stem cells (BMSCs) and showed good effect on cell proliferation.

KW - Bioceramic

KW - Bone Scaffold

KW - Gradient Porosity

KW - Stereolithography

UR - http://www.scopus.com/inward/record.url?scp=85088034510&partnerID=8YFLogxK

U2 - 10.1016/j.procir.2020.05.138

DO - 10.1016/j.procir.2020.05.138

M3 - Conference article

AN - SCOPUS:85088034510

SN - 2212-8271

VL - 89

SP - 170

EP - 175

JO - Procedia CIRP

JF - Procedia CIRP

T2 - 4th CIRP Conference on Biomanufacturing, CIRP-BioM 2019

Y2 - 12 December 2019 through 15 December 2019

ER -

Design and Characterization of Hydroxyapatite Scaffolds Fabricated by Stereolithography for Bone Tissue Engineering Application

Abstract

Keywords

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