Colorectal liver metastasis: molecular mechanism and interventional therapy

Hui Zhou; Zhongtao Liu; Yongxiang Wang; Xiaoyong Wen; Eric H. Amador; Liqin Yuan; Xin Ran; Li Xiong; Yuping Ran; Wei Chen; Yu Wen

doi:10.1038/s41392-022-00922-2

Colorectal liver metastasis: molecular mechanism and interventional therapy

Hui Zhou, Zhongtao Liu, Yongxiang Wang, Xiaoyong Wen, Eric H. Amador, Liqin Yuan, Xin Ran, Li Xiong^*, Yuping Ran, Wei Chen^*, Yu Wen^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

124 Citations (Scopus)

Abstract

Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.

Original language	English
Article number	70
Journal	Signal Transduction and Targeted Therapy
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41392-022-00922-2
Publication status	Published - Dec 2022
Externally published	Yes

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title = "Colorectal liver metastasis: molecular mechanism and interventional therapy",

abstract = "Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.",

author = "Hui Zhou and Zhongtao Liu and Yongxiang Wang and Xiaoyong Wen and Amador, {Eric H.} and Liqin Yuan and Xin Ran and Li Xiong and Yuping Ran and Wei Chen and Yu Wen",

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doi = "10.1038/s41392-022-00922-2",

language = "English",

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TY - JOUR

T1 - Colorectal liver metastasis

T2 - molecular mechanism and interventional therapy

AU - Zhou, Hui

AU - Liu, Zhongtao

AU - Wang, Yongxiang

AU - Wen, Xiaoyong

AU - Amador, Eric H.

AU - Yuan, Liqin

AU - Ran, Xin

AU - Xiong, Li

AU - Ran, Yuping

AU - Chen, Wei

AU - Wen, Yu

PY - 2022/12

Y1 - 2022/12

N2 - Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.

AB - Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.

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U2 - 10.1038/s41392-022-00922-2

DO - 10.1038/s41392-022-00922-2

M3 - Review article

C2 - 35246503

AN - SCOPUS:85125774430

SN - 2095-9907

VL - 7

JO - Signal Transduction and Targeted Therapy

JF - Signal Transduction and Targeted Therapy

IS - 1

M1 - 70

ER -

Colorectal liver metastasis: molecular mechanism and interventional therapy

Abstract

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