TY - JOUR
T1 - A powerful combination of copper-cysteamine nanoparticles with potassium iodide for bacterial destruction
AU - Zhen, Xiumei
AU - Chudal, Lalit
AU - Pandey, Nil Kanatha
AU - Phan, Jonathan
AU - Ran, Xin
AU - Amandor, Eric
AU - Huang, Xuejing
AU - Johnson, Omar
AU - Ran, Yuping
AU - Chen, Wei
AU - Hamblin, Michael R.
AU - Huang, Liyi
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/5
Y1 - 2020/5
N2 - Herein, for the first time, we demonstrate that the combination of copper-cysteamine (Cu-Cy) nanoparticles (NPs) and potassium iodide (KI) can significantly inactivate both Gram-positive MRSA and Gram-negative E. coli. To uncover the mystery of the killing, the interaction of KI with Cu-Cy NPs was investigated systematically and the products from their interaction were identified. No copper ions were released after adding KI to Cu-Cy NPs in cell-free medium and, therefore, it is reasonable to conclude that the Fenton reaction induced by copper ions is not responsible for the bacterial killing. Based on the observations, we propose that the major killing mechanism involves the generation of toxic species, such as hydrogen peroxide, triiodide ions, iodide ions, singlet oxygen, and iodine molecules. Overall, the powerful combination of Cu-Cy NPs and KI has good potential as an independent treatment or a complementary antibiotic treatment to infectious diseases.
AB - Herein, for the first time, we demonstrate that the combination of copper-cysteamine (Cu-Cy) nanoparticles (NPs) and potassium iodide (KI) can significantly inactivate both Gram-positive MRSA and Gram-negative E. coli. To uncover the mystery of the killing, the interaction of KI with Cu-Cy NPs was investigated systematically and the products from their interaction were identified. No copper ions were released after adding KI to Cu-Cy NPs in cell-free medium and, therefore, it is reasonable to conclude that the Fenton reaction induced by copper ions is not responsible for the bacterial killing. Based on the observations, we propose that the major killing mechanism involves the generation of toxic species, such as hydrogen peroxide, triiodide ions, iodide ions, singlet oxygen, and iodine molecules. Overall, the powerful combination of Cu-Cy NPs and KI has good potential as an independent treatment or a complementary antibiotic treatment to infectious diseases.
KW - Bacterial killing
KW - Copper
KW - Copper-cysteamine
KW - Nanoparticles
KW - Photodynamic therapy
KW - Photosensitizer
KW - Potassium iodide
KW - Reactive iodine species
UR - http://www.scopus.com/inward/record.url?scp=85077801808&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2020.110659
DO - 10.1016/j.msec.2020.110659
M3 - Article
C2 - 32204087
AN - SCOPUS:85077801808
SN - 0928-4931
VL - 110
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
M1 - 110659
ER -