TY - JOUR
T1 - A new type of cuprous-cysteamine sensitizers
T2 - Synthesis, optical properties and potential applications
AU - Wang, Y.
AU - Alkhaldi, N. D.
AU - Pandey, N. K.
AU - Chudal, L.
AU - Wang, L. Y.
AU - Lin, L. W.
AU - Zhang, M. B.
AU - Yong, Y. X.
AU - Amador, E. H.
AU - Huda, M. N.
AU - Chen, W.
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/7
Y1 - 2021/7
N2 - Herein, for the first time, we report a series of cuprous-cysteamine (Cu-Cy-X, X = F, Cl, Br, and I)) sensitizers that possess tunable fluorescence from orange to yellow. The Cu-Cy-X can generate reactive oxygen species (ROS), including singlet oxygen (1O2) in the order of Cu-Cy-I > Cu-Cy-Br > Cu-Cy-Cl ≈ Cu-Cy-F under UV and microwave excitation. Further study revealed that Cu-Cy-X has stability in the order of Cu-Cy-I > Cu-Cy-Br > Cu-Cy-Cl ≈ Cu-Cy-F. In this work, a detailed synthesis technique, crystal structure, optical properties, and mechanism of the observed trend in 1O2 generation, luminescence spectra, and anticancer effect are discussed in both theoretical and experimental points of view. These new materials will open a new door for photodynamic therapy and many other potential applications such as sensing, lighting, displays, labeling, and medical imaging.
AB - Herein, for the first time, we report a series of cuprous-cysteamine (Cu-Cy-X, X = F, Cl, Br, and I)) sensitizers that possess tunable fluorescence from orange to yellow. The Cu-Cy-X can generate reactive oxygen species (ROS), including singlet oxygen (1O2) in the order of Cu-Cy-I > Cu-Cy-Br > Cu-Cy-Cl ≈ Cu-Cy-F under UV and microwave excitation. Further study revealed that Cu-Cy-X has stability in the order of Cu-Cy-I > Cu-Cy-Br > Cu-Cy-Cl ≈ Cu-Cy-F. In this work, a detailed synthesis technique, crystal structure, optical properties, and mechanism of the observed trend in 1O2 generation, luminescence spectra, and anticancer effect are discussed in both theoretical and experimental points of view. These new materials will open a new door for photodynamic therapy and many other potential applications such as sensing, lighting, displays, labeling, and medical imaging.
KW - Cuprous-cysteamine
KW - Density functional theory (DFT)
KW - Luminescence
KW - Microwave
KW - Photodynamic therapy
KW - Reactive oxygen species
KW - Sensitizer
KW - Singlet oxygen
UR - http://www.scopus.com/inward/record.url?scp=85106925346&partnerID=8YFLogxK
U2 - 10.1016/j.mtphys.2021.100435
DO - 10.1016/j.mtphys.2021.100435
M3 - Article
AN - SCOPUS:85106925346
SN - 2542-5293
VL - 19
JO - Materials Today Physics
JF - Materials Today Physics
M1 - 100435
ER -