A new design of the continual reassessment method

Weijia Zhang, Xikui Wang*, Po Yang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We propose a new design of the continual reassessment method and systematically evaluate its performance on certain operating measures to satisfy the requirements of collective and individual ethics. Simulation results are derived to compare the new design with currently available designs on criteria BEARS: Benchmark, Efficiency, Accuracy, Reliability, Safety. Overall, the new design performs well and safely avoids toxic doses (hence safeguarding individual ethics) while reliably identifying the maximum tolerated dose (hence protecting collective ethics).

Original languageEnglish
Pages (from-to)2015-2024
Number of pages10
JournalCommunications in Statistics: Simulation and Computation
Volume50
Issue number7
DOIs
Publication statusPublished - 2021
Externally publishedYes

Keywords

  • Bayesian method
  • Continual reassessment method
  • Maximum tolerated dose
  • Phase I clinical trial
  • Toxicity

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