A High-Performance Polymer Composite Column for Coronavirus Nucleic Acid Purification

Akli Zarouri, Aaron Barnes, Hamada Aboubakr, Vinni Thekkudan Novi, Qiuchen Dong, Andrew Nelson, Sagar Goyal, Abdennour Abbas*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Here, we report the development of a novel polymer composite (PC) purification column and kit. The performance of the PC columns was compared to conventional silica gel (SG) columns for the purification of nucleic acids from coronaviruses, including SARS-CoV-2, in 82 clinical samples. The results shows that PC-based purification outperforms silica gel (SG)-based purification by enabling a higher sensitivity (94%), accuracy (97%), and by eliminating false positives (100% specificity). The high specificity is critical for efficient patient triage and resource management during pandemics. Furthermore, PC-based purification exhibits three times higher analytical precision than a commonly used SG-based nucleic acid purification thereby enabling a more accurate quantification of viral loads and higher reproducibility.

Original languageEnglish
Article number1138
JournalScientific Reports
Issue number1
Publication statusPublished - 11 Jan 2024
Externally publishedYes


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