Zebrafish models to study drug abuse-related phenotypes

Adam Stewart; Keith Wong; Jonathan Cachat; Siddharth Gaikwad; Evan Kyzar; Nadine Wu; Peter Hart; Valerie Piet; Eli Utterback; Marco Elegante; David Tien; Allan V. Kalueff

doi:10.1515/RNS.2011.011

Zebrafish models to study drug abuse-related phenotypes

Adam Stewart, Keith Wong, Jonathan Cachat, Siddharth Gaikwad, Evan Kyzar, Nadine Wu, Peter Hart, Valerie Piet, Eli Utterback, Marco Elegante, David Tien, Allan V. Kalueff^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

123 Citations (Scopus)

Abstract

Mounting evidence implicates the zebrafish ( Danio rerio ) as a promising model species for reward and addiction research. Modeling drug abuse-related behavior in both adult and larval zebrafish produced a wealth of clinically translatable data, also demonstrating their sensitivity to various drugs of abuse and the ability to develop tolerance. Several studies have also applied withdrawal paradigms to model the adverse effects of drug abuse in zebrafish. In this review, we summarize recent findings of a wide spectrum of zebrafish drug abuse-related behavioral and physiological phenotypes, discuss the existing challenges, and outline potential future directions of research in this field.

Original language	English
Pages (from-to)	95-105
Number of pages	11
Journal	Reviews in the Neurosciences
Volume	22
Issue number	1
DOIs	https://doi.org/10.1515/RNS.2011.011
Publication status	Published - Feb 2011
Externally published	Yes

Keywords

Anxiety
Cortisol
Drug abuse
Stress tolerance
Withdrawal
Zebrafish

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1515/RNS.2011.011

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AU - Stewart, Adam

AU - Wong, Keith

AU - Cachat, Jonathan

AU - Gaikwad, Siddharth

AU - Kyzar, Evan

AU - Wu, Nadine

AU - Hart, Peter

AU - Piet, Valerie

AU - Utterback, Eli

AU - Elegante, Marco

AU - Tien, David

AU - Kalueff, Allan V.

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AB - Mounting evidence implicates the zebrafish ( Danio rerio ) as a promising model species for reward and addiction research. Modeling drug abuse-related behavior in both adult and larval zebrafish produced a wealth of clinically translatable data, also demonstrating their sensitivity to various drugs of abuse and the ability to develop tolerance. Several studies have also applied withdrawal paradigms to model the adverse effects of drug abuse in zebrafish. In this review, we summarize recent findings of a wide spectrum of zebrafish drug abuse-related behavioral and physiological phenotypes, discuss the existing challenges, and outline potential future directions of research in this field.

KW - Anxiety

KW - Cortisol

KW - Drug abuse

KW - Stress tolerance

KW - Withdrawal

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JF - Reviews in the Neurosciences

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Zebrafish models to study drug abuse-related phenotypes

Abstract

Keywords

UN SDGs

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