TY - JOUR
T1 - Zebrafish models of autism spectrum disorder
AU - Meshalkina, Daria A.
AU - N. Kizlyk, Marina
AU - V. Kysil, Elana
AU - Collier, Adam D.
AU - Echevarria, David J.
AU - Abreu, Murilo S.
AU - Barcellos, Leonardo J.G.
AU - Song, Cai
AU - Warnick, Jason E.
AU - Kyzar, Evan J.
AU - Kalueff, Allan V.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/1
Y1 - 2018/1
N2 - Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by motor, social and cognitive deficits that develop early during childhood. The pathogenesis of ASD is not well characterized and involves a multifaceted interaction between genetic, neurobiological and environmental factors. Animal (experimental) models possess evolutionarily conserved behaviors and molecular pathways that are highly relevant for studying ASD. The zebrafish (Danio rerio) is a relatively new animal model with promise for understanding the pathogenesis of complex brain disorders and discovering novel treatments. As a highly social and genetically tractable organism, zebrafish have recently been applied to model a variety of deficits relevant to ASD. Here, we discuss the developing utility of zebrafish models of ASD, as well as current behavioral, toxicological and genetic models of ASD, and future directions of research in this field.
AB - Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by motor, social and cognitive deficits that develop early during childhood. The pathogenesis of ASD is not well characterized and involves a multifaceted interaction between genetic, neurobiological and environmental factors. Animal (experimental) models possess evolutionarily conserved behaviors and molecular pathways that are highly relevant for studying ASD. The zebrafish (Danio rerio) is a relatively new animal model with promise for understanding the pathogenesis of complex brain disorders and discovering novel treatments. As a highly social and genetically tractable organism, zebrafish have recently been applied to model a variety of deficits relevant to ASD. Here, we discuss the developing utility of zebrafish models of ASD, as well as current behavioral, toxicological and genetic models of ASD, and future directions of research in this field.
KW - Autism spectrum disorder
KW - Behavioral models
KW - Genetic models
KW - Toxicological models
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85012910432&partnerID=8YFLogxK
U2 - 10.1016/j.expneurol.2017.02.004
DO - 10.1016/j.expneurol.2017.02.004
M3 - Review article
C2 - 28163161
AN - SCOPUS:85012910432
SN - 0014-4886
VL - 299
SP - 207
EP - 216
JO - Experimental Neurology
JF - Experimental Neurology
ER -